Public confidence in science in the United States remains high compared to other civic, cultural, and governmental institutions, though it has declined over the past five years. This decline is not specific to science but is similar to or less pronounced than declines in confidence in other institutions. Despite this, the public still holds high levels of confidence in scientists' competence, trustworthiness, and honesty. However, many U.S. adults question whether scientists share their values or can overcome personal biases when presenting conclusions. For example, when asked whether scientists would publish findings that contradict their organization's interests, 70% of respondents believed scientists would not publish the finding. The public generally agrees on certain actions scientists should take, such as disclosing their funders and being open to changing their minds based on new evidence. Eighty-four percent of U.S. adults believe it is important for scientists to disclose their funders, and 92% believe it is important for scientists to be open to changing their minds based on new evidence. These findings suggest that the public has clear expectations for how scientists should act. Public confidence in science is closely linked to real-world outcomes, such as willingness to take life-saving vaccines. Studies show that trust in health authorities is a significant predictor of willingness to vaccinate. Lower levels of trust in public health institutions and spokespersons are associated with acceptance of misinformation about COVID-19 and vaccines, which in turn is linked to lower willingness to vaccinate. The research also reveals that the public generally views scientists as competent, trustworthy, and ethical. However, there is more mixed opinion about whether scientists share their values, protect their work from bias, and follow scientific best practices when it goes against their self-interests. The public is heavily in favor of scientists disclosing their funders and changing their minds based on new evidence. To increase public confidence in science, researchers, scientific organizations, and the scientific community need to commit to conducting, communicating, and correcting scientific research in ways that merit and earn public confidence. This includes promoting transparency, reproducibility, and accountability in scientific practices. The Strategic Council for Research Excellence, Integrity, and Trust is working to address these issues and improve public understanding and trust in science.Public confidence in science in the United States remains high compared to other civic, cultural, and governmental institutions, though it has declined over the past five years. This decline is not specific to science but is similar to or less pronounced than declines in confidence in other institutions. Despite this, the public still holds high levels of confidence in scientists' competence, trustworthiness, and honesty. However, many U.S. adults question whether scientists share their values or can overcome personal biases when presenting conclusions. For example, when asked whether scientists would publish findings that contradict their organization's interests, 70% of respondents believed scientists would not publish the finding. The public generally agrees on certain actions scientists should take, such as disclosing their funders and being open to changing their minds based on new evidence. Eighty-four percent of U.S. adults believe it is important for scientists to disclose their funders, and 92% believe it is important for scientists to be open to changing their minds based on new evidence. These findings suggest that the public has clear expectations for how scientists should act. Public confidence in science is closely linked to real-world outcomes, such as willingness to take life-saving vaccines. Studies show that trust in health authorities is a significant predictor of willingness to vaccinate. Lower levels of trust in public health institutions and spokespersons are associated with acceptance of misinformation about COVID-19 and vaccines, which in turn is linked to lower willingness to vaccinate. The research also reveals that the public generally views scientists as competent, trustworthy, and ethical. However, there is more mixed opinion about whether scientists share their values, protect their work from bias, and follow scientific best practices when it goes against their self-interests. The public is heavily in favor of scientists disclosing their funders and changing their minds based on new evidence. To increase public confidence in science, researchers, scientific organizations, and the scientific community need to commit to conducting, communicating, and correcting scientific research in ways that merit and earn public confidence. This includes promoting transparency, reproducibility, and accountability in scientific practices. The Strategic Council for Research Excellence, Integrity, and Trust is working to address these issues and improve public understanding and trust in science.