The article presents a novel, mild, and operationally simple strategy for the direct trifluoromethylation of unactivated arenes and heteroarenes using photoredox catalysis. The method involves the use of commercial photocatalysts and a household light bulb to generate the CF3 radical, which then selectively adds to the most electron-rich position of the substrate. This approach overcomes the limitations of traditional cross-coupling methods, which often require pre-functionalization and can be less efficient. The authors demonstrate the broad utility of this transformation by successfully trifluoromethylating a variety of heteroaromatic and aromatic systems, including biologically active molecules. The benefits of this method include its amenability to late-stage synthetic applications, the ability to protect against in vivo metabolic oxidation, and the potential for rapid testing of fluorinated analogues. The study highlights the potential of this technology in drug discovery and development, particularly in addressing the challenges associated with the enzymatic metabolism of drugs.The article presents a novel, mild, and operationally simple strategy for the direct trifluoromethylation of unactivated arenes and heteroarenes using photoredox catalysis. The method involves the use of commercial photocatalysts and a household light bulb to generate the CF3 radical, which then selectively adds to the most electron-rich position of the substrate. This approach overcomes the limitations of traditional cross-coupling methods, which often require pre-functionalization and can be less efficient. The authors demonstrate the broad utility of this transformation by successfully trifluoromethylating a variety of heteroaromatic and aromatic systems, including biologically active molecules. The benefits of this method include its amenability to late-stage synthetic applications, the ability to protect against in vivo metabolic oxidation, and the potential for rapid testing of fluorinated analogues. The study highlights the potential of this technology in drug discovery and development, particularly in addressing the challenges associated with the enzymatic metabolism of drugs.