The article reviews the role of tumor-associated macrophages (TAMs) in tumor metastasis and discusses potential therapeutic strategies targeting TAMs. TAMs play a crucial role in creating an immunosuppressive tumor microenvironment (TME) by producing cytokines, chemokines, growth factors, and inhibitory immune checkpoint proteins, which facilitate the metastatic cascade of cancer cells. The article highlights the regulatory networks of TAM polarization and the mechanisms underlying TAM-induced metastasis. It also discusses the potential applications of TAM-focused therapeutic strategies in clinical cancer treatment, including agents that target TAM survival, suppress M2 polarization, and inhibit macrophage recruitment. The review emphasizes the importance of understanding the complex interactions within the TME and the need for further research to develop effective TAM-targeted therapies.The article reviews the role of tumor-associated macrophages (TAMs) in tumor metastasis and discusses potential therapeutic strategies targeting TAMs. TAMs play a crucial role in creating an immunosuppressive tumor microenvironment (TME) by producing cytokines, chemokines, growth factors, and inhibitory immune checkpoint proteins, which facilitate the metastatic cascade of cancer cells. The article highlights the regulatory networks of TAM polarization and the mechanisms underlying TAM-induced metastasis. It also discusses the potential applications of TAM-focused therapeutic strategies in clinical cancer treatment, including agents that target TAM survival, suppress M2 polarization, and inhibit macrophage recruitment. The review emphasizes the importance of understanding the complex interactions within the TME and the need for further research to develop effective TAM-targeted therapies.