The article discusses the importance of tumor angiogenesis and vascular normalization as therapeutic targets in cancer treatment. Tumor blood vessels are characterized by their immaturity and poor functionality, which can lead to hypoxia, reduced immune cell infiltration, and increased metastatic risk. Anti-angiogenic therapies aim to correct these issues through vascular normalization, which restores proper blood vessel function and enhances the effectiveness of anticancer treatments. The review highlights the key mechanisms involved in tumor angiogenesis, including the role of growth factors like VEGF, and explores potential signaling pathways for achieving vascular normalization. It also provides an overview of physiological blood vessels, their anatomy, and the process of angiogenesis, emphasizing the endothelial tip/stalk cell concept and the role of the Notch pathway in regulating this process.The article discusses the importance of tumor angiogenesis and vascular normalization as therapeutic targets in cancer treatment. Tumor blood vessels are characterized by their immaturity and poor functionality, which can lead to hypoxia, reduced immune cell infiltration, and increased metastatic risk. Anti-angiogenic therapies aim to correct these issues through vascular normalization, which restores proper blood vessel function and enhances the effectiveness of anticancer treatments. The review highlights the key mechanisms involved in tumor angiogenesis, including the role of growth factors like VEGF, and explores potential signaling pathways for achieving vascular normalization. It also provides an overview of physiological blood vessels, their anatomy, and the process of angiogenesis, emphasizing the endothelial tip/stalk cell concept and the role of the Notch pathway in regulating this process.