This review discusses the role of tumor suppressors in regulating cellular metabolism and their potential impact on cancer growth. It highlights how growing tumors face metabolic challenges, including meeting the increased demands of cell proliferation and surviving environmental fluctuations in nutrient and oxygen availability. The review explores the metabolic reprogramming that occurs in cancer cells, particularly the switch from oxidative phosphorylation to aerobic glycolysis, known as the "Warburg effect." It also examines the involvement of key metabolic enzymes and pathways, such as pyruvate kinase-M2 (PK-M2) and the pentose phosphate pathway, in tumor cell growth and proliferation. The role of tumor suppressors like PTEN, LKB1, and p53 in regulating metabolic pathways and their implications for cancer progression are discussed. Additionally, the review covers the importance of metabolic adaptation mechanisms, such as AMP-activated protein kinase (AMPK) and hypoxia-inducible factor 1 (HIF1α), in maintaining cellular viability under stressful conditions. The authors conclude by emphasizing the potential of targeting metabolic pathways as a therapeutic strategy in cancer treatment.This review discusses the role of tumor suppressors in regulating cellular metabolism and their potential impact on cancer growth. It highlights how growing tumors face metabolic challenges, including meeting the increased demands of cell proliferation and surviving environmental fluctuations in nutrient and oxygen availability. The review explores the metabolic reprogramming that occurs in cancer cells, particularly the switch from oxidative phosphorylation to aerobic glycolysis, known as the "Warburg effect." It also examines the involvement of key metabolic enzymes and pathways, such as pyruvate kinase-M2 (PK-M2) and the pentose phosphate pathway, in tumor cell growth and proliferation. The role of tumor suppressors like PTEN, LKB1, and p53 in regulating metabolic pathways and their implications for cancer progression are discussed. Additionally, the review covers the importance of metabolic adaptation mechanisms, such as AMP-activated protein kinase (AMPK) and hypoxia-inducible factor 1 (HIF1α), in maintaining cellular viability under stressful conditions. The authors conclude by emphasizing the potential of targeting metabolic pathways as a therapeutic strategy in cancer treatment.