Tumour microvesicles contain DNA, RNA, and proteins that reflect the genetic status of the tumour, including amplified oncogenes such as c-Myc. These microvesicles also carry high levels of retrotransposon RNA transcripts, particularly from human endogenous retroviruses like LINE-1 and Alu elements. The study found that these transposable elements can be transferred to normal cells, suggesting that tumour microvesicles may serve as a source of genetic information for horizontal gene transfer and potential blood biomarkers for cancer. The findings expand the nucleic acid content of tumour microvesicles to include elevated levels of specific coding and non-coding RNA and DNA, mutated and amplified oncogene sequences, and transposable elements. This research highlights the potential of tumour microvesicles as a diagnostic tool for cancer and provides insights into intercellular genetic communication.Tumour microvesicles contain DNA, RNA, and proteins that reflect the genetic status of the tumour, including amplified oncogenes such as c-Myc. These microvesicles also carry high levels of retrotransposon RNA transcripts, particularly from human endogenous retroviruses like LINE-1 and Alu elements. The study found that these transposable elements can be transferred to normal cells, suggesting that tumour microvesicles may serve as a source of genetic information for horizontal gene transfer and potential blood biomarkers for cancer. The findings expand the nucleic acid content of tumour microvesicles to include elevated levels of specific coding and non-coding RNA and DNA, mutated and amplified oncogene sequences, and transposable elements. This research highlights the potential of tumour microvesicles as a diagnostic tool for cancer and provides insights into intercellular genetic communication.