A new nanostructured plasmonic platform is introduced for the sensitive detection and discrimination of chiral molecules. This achiral plasmonic system enhances the interaction between light and matter, enabling precise measurement, differentiation, and quantification of enantiomeric mixtures. The system exhibits a 13 orders of magnitude higher detection sensitivity for chiral enantiomers compared to conventional VCD spectroscopic techniques. The platform's simplicity, tunability, and exceptional sensitivity make it highly suitable for enantiomer classification in drug design, pharmaceuticals, and biological applications. The system utilizes a gold hole-disk array on a silicon dioxide cavity, which generates localized surface plasmon resonances (LSPRs) and enhances optical chiral density. The design suppresses far-field chiral signals, allowing the chiral signal from the molecule to dominate. The system is capable of detecting a wide range of chiral compounds, including thalidomide, with high sensitivity and accuracy. It can distinguish between different concentrations and enantiomeric excesses of molecules, even at very low concentrations. The system's performance is validated through experimental measurements and simulations. The results show a significant enhancement in the dissymmetry factor, indicating strong chiral interactions. The system's ability to detect ultralow enantiomeric excesses makes it valuable for applications requiring high sensitivity and accuracy in chiral molecule detection. The platform's robustness, ease of fabrication, and fast measurement times make it an ideal tool for on-chip surface-enhanced ultrasensitive chirality detection in biomedical research and pharmaceutical industries.A new nanostructured plasmonic platform is introduced for the sensitive detection and discrimination of chiral molecules. This achiral plasmonic system enhances the interaction between light and matter, enabling precise measurement, differentiation, and quantification of enantiomeric mixtures. The system exhibits a 13 orders of magnitude higher detection sensitivity for chiral enantiomers compared to conventional VCD spectroscopic techniques. The platform's simplicity, tunability, and exceptional sensitivity make it highly suitable for enantiomer classification in drug design, pharmaceuticals, and biological applications. The system utilizes a gold hole-disk array on a silicon dioxide cavity, which generates localized surface plasmon resonances (LSPRs) and enhances optical chiral density. The design suppresses far-field chiral signals, allowing the chiral signal from the molecule to dominate. The system is capable of detecting a wide range of chiral compounds, including thalidomide, with high sensitivity and accuracy. It can distinguish between different concentrations and enantiomeric excesses of molecules, even at very low concentrations. The system's performance is validated through experimental measurements and simulations. The results show a significant enhancement in the dissymmetry factor, indicating strong chiral interactions. The system's ability to detect ultralow enantiomeric excesses makes it valuable for applications requiring high sensitivity and accuracy in chiral molecule detection. The platform's robustness, ease of fabrication, and fast measurement times make it an ideal tool for on-chip surface-enhanced ultrasensitive chirality detection in biomedical research and pharmaceutical industries.