A patient with pseudomembranous colitis had multiple relapses, each accompanied by the presence of Clostridium difficile (C. difficile) or its cytotoxic product in stools. After vancomycin treatment, the organism disappeared, and maintenance therapy with oral vancomycin 125 mg every 8 hours controlled diarrhea and kept stools negative for C. difficile and its cytotoxic product for 10 weeks. The patient had no adverse reactions to vancomycin. The relapses after adequate vancomycin treatment suggest that ischaemia may promote recolonization of C. difficile. The patient's condition was associated with severe chronic bowel ischaemia and no prior antibiotic use. The study questions the sole role of C. difficile in pseudomembranous colitis, noting that the organism can be present without causing illness. Ischaemia due to capillary microthrombosis may contribute to mucosal necrosis. Pseudomembranous colitis is more common in patients with cardiovascular disease. The patient's case highlights the importance of considering ischaemic processes in relapses. Antibiotics should be used cautiously in ischaemic bowel disease. Stools should be tested for C. difficile in patients with pseudomembranous colitis. Protective isolation may be necessary for patients with ischaemic bowel disease. A small maintenance dose of vancomycin was effective and safe in preventing relapses. The 12-minute walking test is a useful measure of exercise tolerance. However, shorter tests, such as 2- or 6-minute tests, were found to be equally reproducible and correlated highly with the 12-minute test. The 12-minute test showed higher variance, likely due to greater random variation. The 2-minute test was equally reproducible and required practice. Shorter tests are easier for patients and investigators but may be less discriminatory. The 6-minute walk test may be a sensible compromise. A high-fiber diet reduced clotting factors VIIc, Xc, and factor VIIIAg in non-insulin-dependent diabetics. This suggests that dietary modifications can affect clotting factors, potentially reducing cardiovascular risk. The effects of high-fiber diet on factors VIIc and Xc in non-insulin-dependent diabetics were similar to those seen in hyperlipidaemia treatment. However, no significant effects were observed in insulin-dependent diabetics, possibly due to the nature of insulin-dependent diabetes or exogenous insulin. The study highlights the potential clinical benefits of dietary modifications through their effects on clotting factors. Larger studies are needed to confirm these findings.A patient with pseudomembranous colitis had multiple relapses, each accompanied by the presence of Clostridium difficile (C. difficile) or its cytotoxic product in stools. After vancomycin treatment, the organism disappeared, and maintenance therapy with oral vancomycin 125 mg every 8 hours controlled diarrhea and kept stools negative for C. difficile and its cytotoxic product for 10 weeks. The patient had no adverse reactions to vancomycin. The relapses after adequate vancomycin treatment suggest that ischaemia may promote recolonization of C. difficile. The patient's condition was associated with severe chronic bowel ischaemia and no prior antibiotic use. The study questions the sole role of C. difficile in pseudomembranous colitis, noting that the organism can be present without causing illness. Ischaemia due to capillary microthrombosis may contribute to mucosal necrosis. Pseudomembranous colitis is more common in patients with cardiovascular disease. The patient's case highlights the importance of considering ischaemic processes in relapses. Antibiotics should be used cautiously in ischaemic bowel disease. Stools should be tested for C. difficile in patients with pseudomembranous colitis. Protective isolation may be necessary for patients with ischaemic bowel disease. A small maintenance dose of vancomycin was effective and safe in preventing relapses. The 12-minute walking test is a useful measure of exercise tolerance. However, shorter tests, such as 2- or 6-minute tests, were found to be equally reproducible and correlated highly with the 12-minute test. The 12-minute test showed higher variance, likely due to greater random variation. The 2-minute test was equally reproducible and required practice. Shorter tests are easier for patients and investigators but may be less discriminatory. The 6-minute walk test may be a sensible compromise. A high-fiber diet reduced clotting factors VIIc, Xc, and factor VIIIAg in non-insulin-dependent diabetics. This suggests that dietary modifications can affect clotting factors, potentially reducing cardiovascular risk. The effects of high-fiber diet on factors VIIc and Xc in non-insulin-dependent diabetics were similar to those seen in hyperlipidaemia treatment. However, no significant effects were observed in insulin-dependent diabetics, possibly due to the nature of insulin-dependent diabetes or exogenous insulin. The study highlights the potential clinical benefits of dietary modifications through their effects on clotting factors. Larger studies are needed to confirm these findings.