The authors describe a general liquid-phase method to exfoliate layered compounds, such as MoS₂, WS₂, MoSe₂, MoTe₂, TaSe₂, NbSe₂, NiTe₂, BN, and Bi₂Te₃, into mono- and few-layer flakes in large quantities. This method is insensitive to air and water and can be scaled up for industrial applications. The exfoliated flakes can be dispersed in common solvents, forming individual nano-sheets or films. Electron microscopy confirms the successful exfoliation. The method also allows the preparation of hybrid dispersions and composites, which can be cast into films. WS₂ and MoS₂ effectively reinforce polymers, while WS₂/carbon nanotube hybrid films exhibit high conductivity, making them promising for thermoelectric applications. The versatility of the method extends to other layered materials, including TMDs, graphene, and Bi₂Te₃, suggesting its potential for a wide range of applications.The authors describe a general liquid-phase method to exfoliate layered compounds, such as MoS₂, WS₂, MoSe₂, MoTe₂, TaSe₂, NbSe₂, NiTe₂, BN, and Bi₂Te₃, into mono- and few-layer flakes in large quantities. This method is insensitive to air and water and can be scaled up for industrial applications. The exfoliated flakes can be dispersed in common solvents, forming individual nano-sheets or films. Electron microscopy confirms the successful exfoliation. The method also allows the preparation of hybrid dispersions and composites, which can be cast into films. WS₂ and MoS₂ effectively reinforce polymers, while WS₂/carbon nanotube hybrid films exhibit high conductivity, making them promising for thermoelectric applications. The versatility of the method extends to other layered materials, including TMDs, graphene, and Bi₂Te₃, suggesting its potential for a wide range of applications.