The article reviews the progress and prospects of flexible 2D nanoelectronics over the past decade, highlighting the emergence of graphene and other 2D materials such as transition metal dichalcogenides (TMDs) and hexagonal boron nitride (h-BN). These materials offer unique properties, including high charge mobility, transparency, and mechanical flexibility, making them ideal for flexible electronics. The review discusses the challenges and advancements in device performance, such as high-frequency operation and thermal management, and explores the potential of 2D heterostructures for enhanced functionality. Despite the progress, significant challenges remain, particularly in achieving complementary n- and p-type transistors and optimizing thermal management on soft substrates. The article also emphasizes the importance of large-scale nanomanufacturing for the practical realization of flexible 2D nanoelectronics, with graphene already demonstrating commercial success in smart phone touch panels.The article reviews the progress and prospects of flexible 2D nanoelectronics over the past decade, highlighting the emergence of graphene and other 2D materials such as transition metal dichalcogenides (TMDs) and hexagonal boron nitride (h-BN). These materials offer unique properties, including high charge mobility, transparency, and mechanical flexibility, making them ideal for flexible electronics. The review discusses the challenges and advancements in device performance, such as high-frequency operation and thermal management, and explores the potential of 2D heterostructures for enhanced functionality. Despite the progress, significant challenges remain, particularly in achieving complementary n- and p-type transistors and optimizing thermal management on soft substrates. The article also emphasizes the importance of large-scale nanomanufacturing for the practical realization of flexible 2D nanoelectronics, with graphene already demonstrating commercial success in smart phone touch panels.