This study estimates US personal health care and public health spending from 1996 to 2013, using data from 183 sources. It categorizes spending by condition, age, sex, and type of care. The total personal health care spending was $30.1 trillion, with diabetes having the highest spending in 2013 at $101.4 billion, followed by ischemic heart disease ($88.1 billion) and low back and neck pain ($87.6 billion). Spending on these conditions varied by age, sex, and type of care. Personal health care spending increased for 143 of the 155 conditions, with the largest increases in low back and neck pain and diabetes. Emergency care and retail pharmaceuticals had the fastest annual growth rates. Public health spending was also estimated, with HIV/AIDS having the highest spending in 2013. The study highlights the importance of understanding spending patterns to inform health policy and resource allocation. The findings show that spending on chronic diseases and conditions like diabetes, ischemic heart disease, and low back and neck pain are the largest contributors to health care spending. The study also notes that spending on these conditions varies significantly by age, sex, and type of care. The results have implications for efforts to control US health care spending. The study used a comprehensive set of conditions and adjusted for comorbidities to provide accurate estimates. The study acknowledges limitations, including imperfect data and the need for more detailed data to improve accuracy. The findings emphasize the need for further research to better understand health care spending patterns and inform policy decisions.This study estimates US personal health care and public health spending from 1996 to 2013, using data from 183 sources. It categorizes spending by condition, age, sex, and type of care. The total personal health care spending was $30.1 trillion, with diabetes having the highest spending in 2013 at $101.4 billion, followed by ischemic heart disease ($88.1 billion) and low back and neck pain ($87.6 billion). Spending on these conditions varied by age, sex, and type of care. Personal health care spending increased for 143 of the 155 conditions, with the largest increases in low back and neck pain and diabetes. Emergency care and retail pharmaceuticals had the fastest annual growth rates. Public health spending was also estimated, with HIV/AIDS having the highest spending in 2013. The study highlights the importance of understanding spending patterns to inform health policy and resource allocation. The findings show that spending on chronic diseases and conditions like diabetes, ischemic heart disease, and low back and neck pain are the largest contributors to health care spending. The study also notes that spending on these conditions varies significantly by age, sex, and type of care. The results have implications for efforts to control US health care spending. The study used a comprehensive set of conditions and adjusted for comorbidities to provide accurate estimates. The study acknowledges limitations, including imperfect data and the need for more detailed data to improve accuracy. The findings emphasize the need for further research to better understand health care spending patterns and inform policy decisions.