This review article focuses on the development of ultra-durable Pt-based catalysts for oxygen reduction reaction (ORR) electrocatalysis in proton exchange membrane fuel cells (PEMFCs). Despite the exceptional ORR activity of Pt-based nanocrystals, several issues such as carbon support corrosion, preferential leaching of active metal elements, instability of surface low-coordinated atoms, and sintering/agglomeration of nanocrystals limit the durability of these catalysts. The article discusses the current limitations of Pt-based binary catalysts and presents various structural regulation strategies to improve their durability, including optimization of supports, metal-doped alloys, core/shell structures, intermetallics, and high-entropy alloys. Each strategy is detailed, emphasizing the elimination of the mentioned restrictions. The structure-performance relationship is explained, and the challenges and future research directions are presented to promote the practical application of ultradurable Pt-based catalysts in PEMFC devices.This review article focuses on the development of ultra-durable Pt-based catalysts for oxygen reduction reaction (ORR) electrocatalysis in proton exchange membrane fuel cells (PEMFCs). Despite the exceptional ORR activity of Pt-based nanocrystals, several issues such as carbon support corrosion, preferential leaching of active metal elements, instability of surface low-coordinated atoms, and sintering/agglomeration of nanocrystals limit the durability of these catalysts. The article discusses the current limitations of Pt-based binary catalysts and presents various structural regulation strategies to improve their durability, including optimization of supports, metal-doped alloys, core/shell structures, intermetallics, and high-entropy alloys. Each strategy is detailed, emphasizing the elimination of the mentioned restrictions. The structure-performance relationship is explained, and the challenges and future research directions are presented to promote the practical application of ultradurable Pt-based catalysts in PEMFC devices.