This review discusses the challenges and strategies for improving the durability of Pt-based catalysts for oxygen reduction reaction (ORR) in proton exchange membrane fuel cells (PEMFCs). Despite their high ORR activity, Pt-based catalysts face issues such as corrosion of carbon supports, leaching of active metals, instability of surface atoms, and sintering of nanocrystals. The review summarizes current strategies for enhancing ORR durability, including support optimization, metal-doped alloys, core/shell structures, intermetallics, and high-entropy alloys. It emphasizes the importance of structure-property relationships and the need to address these challenges for practical PEMFC applications. Key strategies include optimizing supports to enhance stability, using heteroatom-doped alloys to improve activity and durability, and designing core/shell structures to protect active sites. The review highlights the role of electronic structure and surface energy in catalytic performance, and presents examples of highly durable Pt-based catalysts, such as Pt/PGC and Pt/Fe–N–C, which show excellent ORR activity and stability. Additionally, the review discusses the use of anisotropic structures and advanced materials like MXene to enhance durability. The study concludes that further research is needed to develop ultradurable Pt-based catalysts for efficient and sustainable PEMFCs.This review discusses the challenges and strategies for improving the durability of Pt-based catalysts for oxygen reduction reaction (ORR) in proton exchange membrane fuel cells (PEMFCs). Despite their high ORR activity, Pt-based catalysts face issues such as corrosion of carbon supports, leaching of active metals, instability of surface atoms, and sintering of nanocrystals. The review summarizes current strategies for enhancing ORR durability, including support optimization, metal-doped alloys, core/shell structures, intermetallics, and high-entropy alloys. It emphasizes the importance of structure-property relationships and the need to address these challenges for practical PEMFC applications. Key strategies include optimizing supports to enhance stability, using heteroatom-doped alloys to improve activity and durability, and designing core/shell structures to protect active sites. The review highlights the role of electronic structure and surface energy in catalytic performance, and presents examples of highly durable Pt-based catalysts, such as Pt/PGC and Pt/Fe–N–C, which show excellent ORR activity and stability. Additionally, the review discusses the use of anisotropic structures and advanced materials like MXene to enhance durability. The study concludes that further research is needed to develop ultradurable Pt-based catalysts for efficient and sustainable PEMFCs.