This review discusses various ultrasonic reactor designs and their applications in sonochemistry, focusing on their operational parameters, advantages, and challenges. Sonochemistry uses ultrasonic waves to enhance chemical reactions, offering benefits such as faster reaction times, higher selectivity, and reduced use of hazardous solvents. Different reactor types, including batch, continuous flow, and microstructured reactors, are analyzed. Batch reactors are cost-effective but have limited scalability, while continuous flow reactors offer higher production yields but face challenges in design and operation. Microstructured reactors improve heat and mass transfer but are prone to clogging. The optimization of parameters such as temperature, ultrasound frequency, and reactor design is crucial for maximizing reaction efficiency. Applications of sonochemistry span biochemical and petrochemical engineering, material synthesis, crystallization, wastewater treatment, extraction, and medicine. Challenges include scalability and commercialization, requiring further research and computational tools. The review highlights the importance of reactor configuration, acoustic field distribution, and operational parameters in achieving efficient sonochemical processes. Key findings include the impact of liquid height, transducer placement, and reactor geometry on cavitation activity. The study also discusses the use of ultrasonic baths, horns, and cup-horns as sound sources, emphasizing their roles in different reactor systems. Overall, the review provides a comprehensive overview of ultrasonic reactor technologies and their potential in various industrial and scientific applications.This review discusses various ultrasonic reactor designs and their applications in sonochemistry, focusing on their operational parameters, advantages, and challenges. Sonochemistry uses ultrasonic waves to enhance chemical reactions, offering benefits such as faster reaction times, higher selectivity, and reduced use of hazardous solvents. Different reactor types, including batch, continuous flow, and microstructured reactors, are analyzed. Batch reactors are cost-effective but have limited scalability, while continuous flow reactors offer higher production yields but face challenges in design and operation. Microstructured reactors improve heat and mass transfer but are prone to clogging. The optimization of parameters such as temperature, ultrasound frequency, and reactor design is crucial for maximizing reaction efficiency. Applications of sonochemistry span biochemical and petrochemical engineering, material synthesis, crystallization, wastewater treatment, extraction, and medicine. Challenges include scalability and commercialization, requiring further research and computational tools. The review highlights the importance of reactor configuration, acoustic field distribution, and operational parameters in achieving efficient sonochemical processes. Key findings include the impact of liquid height, transducer placement, and reactor geometry on cavitation activity. The study also discusses the use of ultrasonic baths, horns, and cup-horns as sound sources, emphasizing their roles in different reactor systems. Overall, the review provides a comprehensive overview of ultrasonic reactor technologies and their potential in various industrial and scientific applications.