This review article provides a comprehensive overview of ultrasonic reactor designs and their applications in various fields. It highlights the benefits and drawbacks of different reactor types, such as batch systems and continuous flow reactors, and discusses the optimization of operating parameters to maximize reaction yields and efficiency. The article also explores the theoretical background of acoustic cavitation and the role of transducers, horns, and boosters in generating ultrasonic waves. Additionally, it reviews specific applications of sonochemistry, including biochemical and petrochemical engineering, material synthesis, crystallization, wastewater treatment, and medical processes. The review emphasizes the need for further research to address scalability challenges and develop computational tools for efficient theoretical studies.This review article provides a comprehensive overview of ultrasonic reactor designs and their applications in various fields. It highlights the benefits and drawbacks of different reactor types, such as batch systems and continuous flow reactors, and discusses the optimization of operating parameters to maximize reaction yields and efficiency. The article also explores the theoretical background of acoustic cavitation and the role of transducers, horns, and boosters in generating ultrasonic waves. Additionally, it reviews specific applications of sonochemistry, including biochemical and petrochemical engineering, material synthesis, crystallization, wastewater treatment, and medical processes. The review emphasizes the need for further research to address scalability challenges and develop computational tools for efficient theoretical studies.