This review article by Ammar A. Oglat and Tala Abukhalil provides a comprehensive overview of ultrasound elastography (USE), a technique that uses sound waves to assess tissue stiffness for diagnostic purposes. The authors discuss the fundamental principles, physics, and limitations of USE, as well as its clinical applications in the liver, kidneys, and breast. Ultrasound elastography has gained significant attention due to its non-invasive nature and ability to provide qualitative and quantitative data on tissue mechanical characteristics. The article highlights the advantages of USE, such as its adaptability, low cost, and wide availability, but also acknowledges the technical challenges and limitations, including operator-dependent variability and the influence of patient anatomy and movement. The review concludes by emphasizing the potential of USE in monitoring disease progression, assessing disease severity, and improving diagnostic accuracy, particularly in liver fibrosis, renal fibrosis, and breast cancer. Despite ongoing advancements, further research is needed to fully realize the potential of USE in clinical settings.This review article by Ammar A. Oglat and Tala Abukhalil provides a comprehensive overview of ultrasound elastography (USE), a technique that uses sound waves to assess tissue stiffness for diagnostic purposes. The authors discuss the fundamental principles, physics, and limitations of USE, as well as its clinical applications in the liver, kidneys, and breast. Ultrasound elastography has gained significant attention due to its non-invasive nature and ability to provide qualitative and quantitative data on tissue mechanical characteristics. The article highlights the advantages of USE, such as its adaptability, low cost, and wide availability, but also acknowledges the technical challenges and limitations, including operator-dependent variability and the influence of patient anatomy and movement. The review concludes by emphasizing the potential of USE in monitoring disease progression, assessing disease severity, and improving diagnostic accuracy, particularly in liver fibrosis, renal fibrosis, and breast cancer. Despite ongoing advancements, further research is needed to fully realize the potential of USE in clinical settings.