2017; 7(5): 1303-1329. doi: 10.7150/thno.18650 | Rosa M.S. Sigrist, Joy Liau, Ahmed El Kaffas, Maria Cristina Chammas, Juergen K. Willmann
This article reviews the principles, techniques, and clinical applications of ultrasound elastography (USE). Elastography is a non-invasive imaging technique that assesses tissue stiffness, which can be used to differentiate between normal and affected tissues in various pathologies. Ultrasound elastography has gained significant attention due to its wide availability, low cost, and ability to provide qualitative and quantitative information. The techniques can be classified into strain imaging, which uses internal or external compression stimuli, and shear wave imaging, which uses ultrasound-generated traveling shear wave stimuli. Strain imaging measures normal strain by applying normal stress, while shear wave imaging measures shear wave speed or Young's modulus by applying dynamic stress. The article discusses the physics behind these techniques, including Hooke's Law and the relationship between elastic moduli. It also reviews the technical limitations of USE, such as operator-dependent measurements and the need for standardized protocols. The clinical applications of USE are highlighted, particularly in liver fibrosis assessment, where it has shown promising results in staging and monitoring disease progression. Other applications in breast, thyroid, prostate, kidney, and lymph node imaging are also discussed, with ongoing research and developments in these areas. The article concludes by emphasizing the potential of USE in providing complementary information to conventional ultrasound, enhancing diagnostic accuracy in various clinical settings.This article reviews the principles, techniques, and clinical applications of ultrasound elastography (USE). Elastography is a non-invasive imaging technique that assesses tissue stiffness, which can be used to differentiate between normal and affected tissues in various pathologies. Ultrasound elastography has gained significant attention due to its wide availability, low cost, and ability to provide qualitative and quantitative information. The techniques can be classified into strain imaging, which uses internal or external compression stimuli, and shear wave imaging, which uses ultrasound-generated traveling shear wave stimuli. Strain imaging measures normal strain by applying normal stress, while shear wave imaging measures shear wave speed or Young's modulus by applying dynamic stress. The article discusses the physics behind these techniques, including Hooke's Law and the relationship between elastic moduli. It also reviews the technical limitations of USE, such as operator-dependent measurements and the need for standardized protocols. The clinical applications of USE are highlighted, particularly in liver fibrosis assessment, where it has shown promising results in staging and monitoring disease progression. Other applications in breast, thyroid, prostate, kidney, and lymph node imaging are also discussed, with ongoing research and developments in these areas. The article concludes by emphasizing the potential of USE in providing complementary information to conventional ultrasound, enhancing diagnostic accuracy in various clinical settings.