This review examines the epidemiology and progression of systemic lupus erythematosus (SLE), focusing on the influence of gender, ethnicity, age, and psychosocial factors. SLE is more prevalent among women, particularly reproductive-age women, and African Americans in the United States. The disease is more frequent and severe in non-white populations and men, with higher mortality rates. Survival rates have improved over the past 50 years, with a 90% survival rate at 5 years post-diagnosis. Socioeconomic status and social support are protective factors, while psychosocial factors like acculturation and discrimination can affect disease progression. The review highlights the need for longitudinal studies that include community-based patients and self-assessment tools to better understand and manage SLE.This review examines the epidemiology and progression of systemic lupus erythematosus (SLE), focusing on the influence of gender, ethnicity, age, and psychosocial factors. SLE is more prevalent among women, particularly reproductive-age women, and African Americans in the United States. The disease is more frequent and severe in non-white populations and men, with higher mortality rates. Survival rates have improved over the past 50 years, with a 90% survival rate at 5 years post-diagnosis. Socioeconomic status and social support are protective factors, while psychosocial factors like acculturation and discrimination can affect disease progression. The review highlights the need for longitudinal studies that include community-based patients and self-assessment tools to better understand and manage SLE.