The article "Understanding Wound Healing in Obesity" by Cotterell et al. explores the impact of obesity on wound healing and the underlying mechanisms. Obesity, characterized by a chronic low-grade inflammatory state, is associated with impaired wound healing due to changes in vascularity, immune responses, and the production of adipokines, cytokines, and chemokines. The authors review the four phases of wound healing—hemostasis, inflammation, proliferation, and remodeling—and highlight how obesity affects each phase. They also discuss animal models used to study wound healing, such as the hypertrophic skin model, wound-induced hair follicle neogenesis (WIHN) model, and excisional wound model, and their limitations. The article emphasizes the need for more research to understand and improve wound healing in obese patients, particularly through the application of existing animal models to study obesity's effects on wound healing. The authors conclude that obesity's impact on wound healing is a critical area for further investigation due to the increasing prevalence of obesity and the associated healthcare costs.The article "Understanding Wound Healing in Obesity" by Cotterell et al. explores the impact of obesity on wound healing and the underlying mechanisms. Obesity, characterized by a chronic low-grade inflammatory state, is associated with impaired wound healing due to changes in vascularity, immune responses, and the production of adipokines, cytokines, and chemokines. The authors review the four phases of wound healing—hemostasis, inflammation, proliferation, and remodeling—and highlight how obesity affects each phase. They also discuss animal models used to study wound healing, such as the hypertrophic skin model, wound-induced hair follicle neogenesis (WIHN) model, and excisional wound model, and their limitations. The article emphasizes the need for more research to understand and improve wound healing in obese patients, particularly through the application of existing animal models to study obesity's effects on wound healing. The authors conclude that obesity's impact on wound healing is a critical area for further investigation due to the increasing prevalence of obesity and the associated healthcare costs.