The article "Unlocking Longevity: The Role of Telomeres and Its Targeting Interventions" by Marlies Schellnegger, Elisabeth Hofmann, Martina Carneletto, and Lars-Peter Kamolz explores the role of telomeres in aging and age-related diseases. Telomeres, the protective caps at the ends of chromosomes, shorten with each cell division, leading to cellular senescence and increased susceptibility to age-related ailments. The authors highlight the importance of understanding telomere biology to develop strategies that mitigate age-related diseases and promote healthy aging. They discuss recent approaches to counteract telomere shortening, including telomerase activators and tankyrase inhibitors, as well as the effects of antioxidants and anti-inflammatory agents. The review emphasizes the need for further research and clinical trials to validate these interventions and their potential benefits in extending lifespan and improving healthspan.The article "Unlocking Longevity: The Role of Telomeres and Its Targeting Interventions" by Marlies Schellnegger, Elisabeth Hofmann, Martina Carneletto, and Lars-Peter Kamolz explores the role of telomeres in aging and age-related diseases. Telomeres, the protective caps at the ends of chromosomes, shorten with each cell division, leading to cellular senescence and increased susceptibility to age-related ailments. The authors highlight the importance of understanding telomere biology to develop strategies that mitigate age-related diseases and promote healthy aging. They discuss recent approaches to counteract telomere shortening, including telomerase activators and tankyrase inhibitors, as well as the effects of antioxidants and anti-inflammatory agents. The review emphasizes the need for further research and clinical trials to validate these interventions and their potential benefits in extending lifespan and improving healthspan.