The article "Unveiling the Mechanisms and Challenges of Cancer Drug Resistance" by Sameer Ullah Khan, Kaneez Fatima, Shariqa Aisha, and Fayaz Malik, discusses the complex mechanisms and challenges associated with cancer drug resistance. The authors highlight that cancer treatment faces significant hurdles due to both innate and acquired resistance, which are governed by genetic, epigenetic, proteomic, metabolic, and micro-environmental factors. They emphasize the need for advanced therapeutic options, such as combination therapy and precision immune therapy, to overcome drug resistance. The review also explores the role of tumor heterogeneity, genetic and epigenetic alterations, cancer stem cells (CSCs), and dysregulated developmental cues in drug resistance. Additionally, it examines the impact of cellular organelles, the tumor microenvironment, and metabolic changes on drug resistance. The authors conclude by discussing emerging therapeutic strategies, including immunological and stem cell-based approaches, that may offer better potential to address the problem of therapy resistance.The article "Unveiling the Mechanisms and Challenges of Cancer Drug Resistance" by Sameer Ullah Khan, Kaneez Fatima, Shariqa Aisha, and Fayaz Malik, discusses the complex mechanisms and challenges associated with cancer drug resistance. The authors highlight that cancer treatment faces significant hurdles due to both innate and acquired resistance, which are governed by genetic, epigenetic, proteomic, metabolic, and micro-environmental factors. They emphasize the need for advanced therapeutic options, such as combination therapy and precision immune therapy, to overcome drug resistance. The review also explores the role of tumor heterogeneity, genetic and epigenetic alterations, cancer stem cells (CSCs), and dysregulated developmental cues in drug resistance. Additionally, it examines the impact of cellular organelles, the tumor microenvironment, and metabolic changes on drug resistance. The authors conclude by discussing emerging therapeutic strategies, including immunological and stem cell-based approaches, that may offer better potential to address the problem of therapy resistance.