The International Journal of Sports Medicine (IJSM) requires all research involving human participants or animals to adhere to ethical standards and national/international laws. Authors must cite this editorial in their methods section to confirm compliance. The 2009 IJSM editorial outlined principles from the Declaration of Helsinki and the Guide for the Care and Use of Laboratory Animals, but has since been updated to include ethical principles from professional associations and treaties, the 2010 edition of the Guide, and the importance of statistical power in research. Research protocols must clearly describe the study, methods, and statistical analysis, considering ethical issues, funding, conflicts of interest, and participant welfare. Informed consent must be obtained, ideally in writing, with exceptions for vulnerable populations. Participants must be informed of risks, benefits, and the right to withdraw. Researchers must ensure the privacy and confidentiality of participants, and consider legal and ethical obligations regarding privacy. For animal research, the Guide for the Care and Use of Laboratory Animals must be followed, including appropriate housing, care, and pain management. The 2010 edition expands on ethics, animal care programs, and housing standards. Evidence suggests many animal studies lack proper reporting, and authors should ensure transparency. In sports medicine, retrospective ethics require consent for research use of data. Placebo use must be justified, with care to avoid harm. Deception must be used only when necessary and participants must be debriefed. Good research practice includes planning, data recording, and reporting results. Statistical power is crucial to ensure studies are neither underpowered nor overpowered, with appropriate sample sizes and confidence limits to assess practical significance. Ethical standards in sports and exercise science research must be strictly followed to ensure participant welfare, scientific integrity, and compliance with legal and ethical guidelines.The International Journal of Sports Medicine (IJSM) requires all research involving human participants or animals to adhere to ethical standards and national/international laws. Authors must cite this editorial in their methods section to confirm compliance. The 2009 IJSM editorial outlined principles from the Declaration of Helsinki and the Guide for the Care and Use of Laboratory Animals, but has since been updated to include ethical principles from professional associations and treaties, the 2010 edition of the Guide, and the importance of statistical power in research. Research protocols must clearly describe the study, methods, and statistical analysis, considering ethical issues, funding, conflicts of interest, and participant welfare. Informed consent must be obtained, ideally in writing, with exceptions for vulnerable populations. Participants must be informed of risks, benefits, and the right to withdraw. Researchers must ensure the privacy and confidentiality of participants, and consider legal and ethical obligations regarding privacy. For animal research, the Guide for the Care and Use of Laboratory Animals must be followed, including appropriate housing, care, and pain management. The 2010 edition expands on ethics, animal care programs, and housing standards. Evidence suggests many animal studies lack proper reporting, and authors should ensure transparency. In sports medicine, retrospective ethics require consent for research use of data. Placebo use must be justified, with care to avoid harm. Deception must be used only when necessary and participants must be debriefed. Good research practice includes planning, data recording, and reporting results. Statistical power is crucial to ensure studies are neither underpowered nor overpowered, with appropriate sample sizes and confidence limits to assess practical significance. Ethical standards in sports and exercise science research must be strictly followed to ensure participant welfare, scientific integrity, and compliance with legal and ethical guidelines.