The American College of Veterinary Internal Medicine (ACVIM) has updated its consensus statement on equine herpesvirus-1 (EHV-1), a highly prevalent and frequently pathogenic infection in equids. The previous statement, published in 2009, addressed pathogenesis, strain variation, epidemiology, diagnostic testing, vaccination, outbreak prevention and control, and treatment. This updated statement is based on four systematic reviews that addressed key questions concerning vaccination, pharmaceutical treatment, pathogenesis, and diagnostic testing. The evidence for successful vaccination and effective treatment of EHV-1 infection is limited, and improvements in experimental design and reporting of results are needed. The statement also updates topics considered in the 2009 version, including pathogenesis, neuropathogenic strains, epidemiology, risk factors, diagnostic testing, vaccination, disease control and prevention, outbreak response, and treatment. The authors recommend vaccination as part of a comprehensive biosecurity program, with awareness of its limitations, and provide guidelines for sampling techniques to detect EHV-1 infection. Despite progress, the ability to vaccinate against or treat EHV-1 sequelae remains limited, and robust studies with adequate statistical power are needed to reliably determine the effectiveness of interventions.The American College of Veterinary Internal Medicine (ACVIM) has updated its consensus statement on equine herpesvirus-1 (EHV-1), a highly prevalent and frequently pathogenic infection in equids. The previous statement, published in 2009, addressed pathogenesis, strain variation, epidemiology, diagnostic testing, vaccination, outbreak prevention and control, and treatment. This updated statement is based on four systematic reviews that addressed key questions concerning vaccination, pharmaceutical treatment, pathogenesis, and diagnostic testing. The evidence for successful vaccination and effective treatment of EHV-1 infection is limited, and improvements in experimental design and reporting of results are needed. The statement also updates topics considered in the 2009 version, including pathogenesis, neuropathogenic strains, epidemiology, risk factors, diagnostic testing, vaccination, disease control and prevention, outbreak response, and treatment. The authors recommend vaccination as part of a comprehensive biosecurity program, with awareness of its limitations, and provide guidelines for sampling techniques to detect EHV-1 infection. Despite progress, the ability to vaccinate against or treat EHV-1 sequelae remains limited, and robust studies with adequate statistical power are needed to reliably determine the effectiveness of interventions.