The Alliance of Genome Resources (Alliance) is a coalition of knowledgebases focused on the genetics and genomics of model organisms, including budding yeast, *Caenorhabditis elegans*, *Drosophila*, zebrafish, frog, laboratory mouse, laboratory rat, and the Gene Ontology Consortium. The Alliance is organized into individual knowledge centers with strong connections to their research communities and a centralized software infrastructure. Over the past two years, the Alliance has made significant progress in harmonizing knowledge, storing, analyzing, and presenting data through a web portal, direct downloads, and APIs. Key developments include enhanced tools for browsing genomes, downloading sequences, mining complex data, visualizing pathways, full-text searching of literature, and sequence similarity searching. The Alliance has also implemented species-specific "landing pages" and plans to add disease-specific portals. Additionally, the Alliance is working towards a central persistent database for curation, data modeling, and an advanced literature curation system with integrated AI/ML. The Alliance's commitment to sustainability and community support is evident through its use of modular, reusable infrastructure components and its recognition as a Core Global Biodata Resource by the Global Biodata Coalition. The Alliance's web portal features landing pages for each model organism, and the recent addition of Xenbase, a Xenopus knowledgebase, highlights the consortium's evolving nature. The Alliance is also developing new features such as a paralogy section, a sequence detail widget, and an updated BLAST tool, enhancing the user experience and efficiency in genetic research. The Alliance's data models are being harmonized using LinkML, and a powerful database system is in place for curation, analysis, and display of data. Security, stability, and backups are ensured through Amazon Web Services (AWS), and the Alliance is committed to long-term data preservation by integrating annotations and resources into external public bioinformatic resources. The Alliance also provides extensive user support, documentation, and community engagement through various channels, including a help desk, online tutorials, and a centralized community forum. Future plans include further harmonization of data, the integration of AI/ML in gene function summarization, and the development of training sets and model managers for ML models.The Alliance of Genome Resources (Alliance) is a coalition of knowledgebases focused on the genetics and genomics of model organisms, including budding yeast, *Caenorhabditis elegans*, *Drosophila*, zebrafish, frog, laboratory mouse, laboratory rat, and the Gene Ontology Consortium. The Alliance is organized into individual knowledge centers with strong connections to their research communities and a centralized software infrastructure. Over the past two years, the Alliance has made significant progress in harmonizing knowledge, storing, analyzing, and presenting data through a web portal, direct downloads, and APIs. Key developments include enhanced tools for browsing genomes, downloading sequences, mining complex data, visualizing pathways, full-text searching of literature, and sequence similarity searching. The Alliance has also implemented species-specific "landing pages" and plans to add disease-specific portals. Additionally, the Alliance is working towards a central persistent database for curation, data modeling, and an advanced literature curation system with integrated AI/ML. The Alliance's commitment to sustainability and community support is evident through its use of modular, reusable infrastructure components and its recognition as a Core Global Biodata Resource by the Global Biodata Coalition. The Alliance's web portal features landing pages for each model organism, and the recent addition of Xenbase, a Xenopus knowledgebase, highlights the consortium's evolving nature. The Alliance is also developing new features such as a paralogy section, a sequence detail widget, and an updated BLAST tool, enhancing the user experience and efficiency in genetic research. The Alliance's data models are being harmonized using LinkML, and a powerful database system is in place for curation, analysis, and display of data. Security, stability, and backups are ensured through Amazon Web Services (AWS), and the Alliance is committed to long-term data preservation by integrating annotations and resources into external public bioinformatic resources. The Alliance also provides extensive user support, documentation, and community engagement through various channels, including a help desk, online tutorials, and a centralized community forum. Future plans include further harmonization of data, the integration of AI/ML in gene function summarization, and the development of training sets and model managers for ML models.