The article reviews the extensive biomonitoring studies that have detected Bisphenol A (BPA) in human tissues, urine, blood, and other fluids, indicating widespread exposure to BPA. These studies, involving thousands of individuals from various countries, consistently found BPA in adults, adolescents, and children. In contrast, two toxicokinetic studies suggested that humans are not internally exposed to BPA, leading to concerns about the reliability of these models for risk assessment. The authors propose several hypotheses to explain the conflicting conclusions between biomonitoring and toxicokinetic studies, emphasizing the need for more comprehensive and accurate methods in biomonitoring studies. They also highlight the importance of considering exposure sources and the potential for contamination in sample collection and storage. The review concludes that the available data clearly indicate that the general population is exposed to BPA and is at risk from internal exposure to unconjugated BPA, which can have adverse health effects.The article reviews the extensive biomonitoring studies that have detected Bisphenol A (BPA) in human tissues, urine, blood, and other fluids, indicating widespread exposure to BPA. These studies, involving thousands of individuals from various countries, consistently found BPA in adults, adolescents, and children. In contrast, two toxicokinetic studies suggested that humans are not internally exposed to BPA, leading to concerns about the reliability of these models for risk assessment. The authors propose several hypotheses to explain the conflicting conclusions between biomonitoring and toxicokinetic studies, emphasizing the need for more comprehensive and accurate methods in biomonitoring studies. They also highlight the importance of considering exposure sources and the potential for contamination in sample collection and storage. The review concludes that the available data clearly indicate that the general population is exposed to BPA and is at risk from internal exposure to unconjugated BPA, which can have adverse health effects.