This literature review comprehensively examines the use of medicinal plants in wound healing, focusing on their phytochemical content and clinical effectiveness. The study was conducted using electronic databases such as Google Scholar, PubMed, Science Direct, Web of Science, SciFinder, Thesis, and Scopus, with search terms including "natural products," "wound healing," and "natural compounds." The review identified 62 families and 109 genera of medicinal plants, which have been studied experimentally and clinically for their wound-healing properties. These plants contain secondary metabolites like flavonoids, alkaloids, saponins, tannins, terpenoids, and phenolic compounds, which act at different stages of the healing process through mechanisms such as anti-inflammatory, antimicrobial, and antioxidant effects. The review highlights the potential of medicinal plants as alternatives to conventional wound treatments, emphasizing their ability to promote collagen synthesis, cell proliferation, and angiogenesis. The study also discusses the classification of wounds, the healing process, and the impact of various factors on wound healing, including diabetes and other systemic conditions. Finally, the review explores the bioactive phytochemicals and their mechanisms of action in wound healing, including essential oils, polyphenols, and flavonoids, and their potential in developing new therapeutic strategies.This literature review comprehensively examines the use of medicinal plants in wound healing, focusing on their phytochemical content and clinical effectiveness. The study was conducted using electronic databases such as Google Scholar, PubMed, Science Direct, Web of Science, SciFinder, Thesis, and Scopus, with search terms including "natural products," "wound healing," and "natural compounds." The review identified 62 families and 109 genera of medicinal plants, which have been studied experimentally and clinically for their wound-healing properties. These plants contain secondary metabolites like flavonoids, alkaloids, saponins, tannins, terpenoids, and phenolic compounds, which act at different stages of the healing process through mechanisms such as anti-inflammatory, antimicrobial, and antioxidant effects. The review highlights the potential of medicinal plants as alternatives to conventional wound treatments, emphasizing their ability to promote collagen synthesis, cell proliferation, and angiogenesis. The study also discusses the classification of wounds, the healing process, and the impact of various factors on wound healing, including diabetes and other systemic conditions. Finally, the review explores the bioactive phytochemicals and their mechanisms of action in wound healing, including essential oils, polyphenols, and flavonoids, and their potential in developing new therapeutic strategies.