This review explores the use of medicinal plants in wound healing, highlighting their potential as alternatives to conventional treatments. A comprehensive search of literature from 2013 to 2023 identified 62 plant families and 109 genera with healing properties. These plants contain secondary metabolites like flavonoids, alkaloids, saponins, tannins, and terpenoids, which exhibit anti-inflammatory, antimicrobial, and antioxidant effects. These compounds promote healing by enhancing collagen synthesis, cell proliferation, and angiogenesis. The healing process involves inflammation, proliferation, and remodeling stages, with inflammation playing a critical role in initiating the healing response. Chronic wounds, particularly in diabetic patients, are often associated with impaired healing due to factors like poor circulation and prolonged inflammation. Medicinal plants, through their bioactive compounds, can help mitigate these issues by reducing inflammation, promoting tissue repair, and enhancing antioxidant defenses. The study also discusses the use of plant-derived compounds in formulations for wound treatment, emphasizing their potential in developing effective and safe therapies. Key findings include the importance of plant-derived compounds in wound healing, their mechanisms of action, and their potential as alternatives to conventional treatments. The review underscores the need for further research into the efficacy and safety of these natural compounds in wound healing.This review explores the use of medicinal plants in wound healing, highlighting their potential as alternatives to conventional treatments. A comprehensive search of literature from 2013 to 2023 identified 62 plant families and 109 genera with healing properties. These plants contain secondary metabolites like flavonoids, alkaloids, saponins, tannins, and terpenoids, which exhibit anti-inflammatory, antimicrobial, and antioxidant effects. These compounds promote healing by enhancing collagen synthesis, cell proliferation, and angiogenesis. The healing process involves inflammation, proliferation, and remodeling stages, with inflammation playing a critical role in initiating the healing response. Chronic wounds, particularly in diabetic patients, are often associated with impaired healing due to factors like poor circulation and prolonged inflammation. Medicinal plants, through their bioactive compounds, can help mitigate these issues by reducing inflammation, promoting tissue repair, and enhancing antioxidant defenses. The study also discusses the use of plant-derived compounds in formulations for wound treatment, emphasizing their potential in developing effective and safe therapies. Key findings include the importance of plant-derived compounds in wound healing, their mechanisms of action, and their potential as alternatives to conventional treatments. The review underscores the need for further research into the efficacy and safety of these natural compounds in wound healing.