This review assesses the efficacy of platelet-rich plasma (PRP) treatments for skin rejuvenation. PRP, an autologous biological product, is rich in growth factors that stimulate fibroblast proliferation and collagen production, leading to improved skin texture, elasticity, and reduced wrinkles. The study analyzed 11 relevant studies published between 2014 and 2021, involving 382 patients. Key findings include significant improvements in skin pore size, texture, wrinkle reduction, pigmented spots, collagen density, hyaluronic acid levels, and protection against ultraviolet damage. Combining PRP with hyaluronic acid showed synergistic effects, particularly enhancing skin elasticity in patients with lower body mass index and firmness in individuals aged 50-60. Standardized PRP preparation protocols are emphasized for future research to ensure consistent quality and efficacy. Overall, PRP monotherapy is considered safe and effective for facial skin rejuvenation, with high patient satisfaction rates and promising results. However, caution is advised due to variations in preparation methods and patient factors.This review assesses the efficacy of platelet-rich plasma (PRP) treatments for skin rejuvenation. PRP, an autologous biological product, is rich in growth factors that stimulate fibroblast proliferation and collagen production, leading to improved skin texture, elasticity, and reduced wrinkles. The study analyzed 11 relevant studies published between 2014 and 2021, involving 382 patients. Key findings include significant improvements in skin pore size, texture, wrinkle reduction, pigmented spots, collagen density, hyaluronic acid levels, and protection against ultraviolet damage. Combining PRP with hyaluronic acid showed synergistic effects, particularly enhancing skin elasticity in patients with lower body mass index and firmness in individuals aged 50-60. Standardized PRP preparation protocols are emphasized for future research to ensure consistent quality and efficacy. Overall, PRP monotherapy is considered safe and effective for facial skin rejuvenation, with high patient satisfaction rates and promising results. However, caution is advised due to variations in preparation methods and patient factors.