Platelet-rich plasma (PRP) is a safe and effective therapy for skin rejuvenation, utilizing autologous blood enriched with various growth factors. This review evaluates the efficacy of PRP treatments for skin rejuvenation. PRP treatment led to significant improvements in multiple facial parameters after one to three sessions, including skin pore size, texture, wrinkle reduction, pigmented spots, collagen density, hyaluronic acid levels, and protection against ultraviolet damage. Combining PRP with hyaluronic acid showed a synergistic effect, particularly enhancing skin elasticity in patients with lower body mass index and firmness in individuals aged 50s and 60s. Incorporating physical and biometric data for assessment proved superior to relying solely on physical observations for evaluating subtle skin quality and structural changes. PRP was first introduced in the 1970s and has since been used in various medical specialties. It has been utilized in dermatology for wound healing, vitiligo, scar revision, tissue regeneration, and skin rejuvenation. PRP treatment improved skin wrinkles, tone, elasticity, skin turgor, and epidermal and dermal thickness. Biometric assessments using the VISIA skin analysis system showed significant improvement in facial wrinkles, texture, skin homogeneity, elasticity, and firmness. Cutometer and skin CT showed significant improvement in skin elasticity and firmness following PRP treatment. PRP treatment also improved skin smoothness, gross elasticity, capacitance, and barrier function. PRP treatment increased the density of dermal collagen and may protect human skin from UV-induced damage by regenerating gene expressions of MMP-1, tyrosinase, fibrillin, and tropoelastin. PRP monotherapy is effective for skin rejuvenation, with improvements observed in various skin parameters. However, further research is needed to determine the optimal treatment protocols and centrifuge settings for PRP preparation. PRP monotherapy is considered safe, with few adverse effects reported, such as pain, discomfort, and bruising at the injection site. However, complications such as infection, contamination, and occlusion can occur. The studies' outcomes should be interpreted cautiously due to the small sample sizes and non-randomized study designs in some studies. Overall, PRP monotherapy is a safe and effective treatment for facial skin rejuvenation, with high patient satisfaction rates, and promising results.Platelet-rich plasma (PRP) is a safe and effective therapy for skin rejuvenation, utilizing autologous blood enriched with various growth factors. This review evaluates the efficacy of PRP treatments for skin rejuvenation. PRP treatment led to significant improvements in multiple facial parameters after one to three sessions, including skin pore size, texture, wrinkle reduction, pigmented spots, collagen density, hyaluronic acid levels, and protection against ultraviolet damage. Combining PRP with hyaluronic acid showed a synergistic effect, particularly enhancing skin elasticity in patients with lower body mass index and firmness in individuals aged 50s and 60s. Incorporating physical and biometric data for assessment proved superior to relying solely on physical observations for evaluating subtle skin quality and structural changes. PRP was first introduced in the 1970s and has since been used in various medical specialties. It has been utilized in dermatology for wound healing, vitiligo, scar revision, tissue regeneration, and skin rejuvenation. PRP treatment improved skin wrinkles, tone, elasticity, skin turgor, and epidermal and dermal thickness. Biometric assessments using the VISIA skin analysis system showed significant improvement in facial wrinkles, texture, skin homogeneity, elasticity, and firmness. Cutometer and skin CT showed significant improvement in skin elasticity and firmness following PRP treatment. PRP treatment also improved skin smoothness, gross elasticity, capacitance, and barrier function. PRP treatment increased the density of dermal collagen and may protect human skin from UV-induced damage by regenerating gene expressions of MMP-1, tyrosinase, fibrillin, and tropoelastin. PRP monotherapy is effective for skin rejuvenation, with improvements observed in various skin parameters. However, further research is needed to determine the optimal treatment protocols and centrifuge settings for PRP preparation. PRP monotherapy is considered safe, with few adverse effects reported, such as pain, discomfort, and bruising at the injection site. However, complications such as infection, contamination, and occlusion can occur. The studies' outcomes should be interpreted cautiously due to the small sample sizes and non-randomized study designs in some studies. Overall, PRP monotherapy is a safe and effective treatment for facial skin rejuvenation, with high patient satisfaction rates, and promising results.