The article "Vaccine hesitancy: the next challenge in the fight against COVID-19" by Amiel A. Dror et al. examines the barriers to full population inoculation against COVID-19, focusing on vaccine hesitancy. The study analyzed 1941 anonymous questionnaires completed by healthcare workers and members of the general Israeli population regarding their acceptance of a potential COVID-19 vaccine. Key findings include: 1. **Healthcare Workers and Risk Perception**: Healthcare staff involved in the care of COVID-19 positive patients and individuals at higher risk of disease were more likely to accept the vaccine. In contrast, parents, nurses, and medical workers not caring for SARS-CoV-2 positive patients expressed higher levels of vaccine hesitancy. 2. **Educational Campaigns**: Interventional educational campaigns targeting populations at risk of vaccine hesitancy are urgently needed to combat misinformation and avoid low inoculation rates. 3. **Demographic and Risk Factors**: The study found that having children was the strongest negative predictor for accepting future vaccination, while male sex and self-perception of disease risk were positive predictors. Current influenza vaccination was also a significant predictor of future vaccine acceptance. 4. **Economic and Job Security**: Unemployment and job insecurity were positive predictors of acceptance, while parenthood was a negative predictor. This could be due to parents' concerns about the potential side effects of the vaccine affecting their ability to care for their children. 5. **Safety Concerns**: Concerns about the vaccine's safety, particularly its rapid development, were the most frequently noted safety considerations among both healthcare workers and the general population. The authors emphasize the need for early and targeted educational campaigns by global or country-specific health institutions to address these concerns and improve vaccination compliance.The article "Vaccine hesitancy: the next challenge in the fight against COVID-19" by Amiel A. Dror et al. examines the barriers to full population inoculation against COVID-19, focusing on vaccine hesitancy. The study analyzed 1941 anonymous questionnaires completed by healthcare workers and members of the general Israeli population regarding their acceptance of a potential COVID-19 vaccine. Key findings include: 1. **Healthcare Workers and Risk Perception**: Healthcare staff involved in the care of COVID-19 positive patients and individuals at higher risk of disease were more likely to accept the vaccine. In contrast, parents, nurses, and medical workers not caring for SARS-CoV-2 positive patients expressed higher levels of vaccine hesitancy. 2. **Educational Campaigns**: Interventional educational campaigns targeting populations at risk of vaccine hesitancy are urgently needed to combat misinformation and avoid low inoculation rates. 3. **Demographic and Risk Factors**: The study found that having children was the strongest negative predictor for accepting future vaccination, while male sex and self-perception of disease risk were positive predictors. Current influenza vaccination was also a significant predictor of future vaccine acceptance. 4. **Economic and Job Security**: Unemployment and job insecurity were positive predictors of acceptance, while parenthood was a negative predictor. This could be due to parents' concerns about the potential side effects of the vaccine affecting their ability to care for their children. 5. **Safety Concerns**: Concerns about the vaccine's safety, particularly its rapid development, were the most frequently noted safety considerations among both healthcare workers and the general population. The authors emphasize the need for early and targeted educational campaigns by global or country-specific health institutions to address these concerns and improve vaccination compliance.