This study evaluates the validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity (baPWV) measurements in patients with coronary artery disease (CAD). The study involved 41 patients with CAD, vasospastic angina, or cardiomyopathy, and compared baPWV with aortic pulse wave velocity (PWV) using a catheter tip with pressure manometer. BaPWV was also measured by two observers and a single observer on different days to assess interobserver and intraobserver reproducibility. The results showed a strong correlation between baPWV and aortic PWV (r = 0.87, p < 0.01), with high interobserver (r = 0.98) and intraobserver (r = 0.87) reproducibility. BaPWV was significantly higher in CAD patients than in non-CAD patients with risk factors, and in non-CAD patients with risk factors compared to healthy subjects without risk factors. The study concludes that baPWV is a valid and reproducible marker of vascular damage, suitable for screening large populations.This study evaluates the validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity (baPWV) measurements in patients with coronary artery disease (CAD). The study involved 41 patients with CAD, vasospastic angina, or cardiomyopathy, and compared baPWV with aortic pulse wave velocity (PWV) using a catheter tip with pressure manometer. BaPWV was also measured by two observers and a single observer on different days to assess interobserver and intraobserver reproducibility. The results showed a strong correlation between baPWV and aortic PWV (r = 0.87, p < 0.01), with high interobserver (r = 0.98) and intraobserver (r = 0.87) reproducibility. BaPWV was significantly higher in CAD patients than in non-CAD patients with risk factors, and in non-CAD patients with risk factors compared to healthy subjects without risk factors. The study concludes that baPWV is a valid and reproducible marker of vascular damage, suitable for screening large populations.