This study aims to produce a value set for the EQ-5D-5L, a new version of the EQ-5D instrument, to support decision-making in the English National Health Service (NHS). The study followed an international research protocol and used a hybrid model to combine time trade-off (TTO) and discrete choice experiment (DCE) data from 996 randomly selected members of the English general public. The resulting value set has a higher minimum value and fewer "worse than dead" states compared to the existing EQ-5D-3L value set. The study found that pain/discomfort and anxiety/depression are the most important health problems, while issues with self-care and usual activities are less significant. The value set will be useful for summarizing EQ-5D-5L data in economic evaluations and resource allocation decisions. The study also addresses methodological issues and provides insights into the preferences of the English population, which can inform decisions in healthcare and health technology assessment.This study aims to produce a value set for the EQ-5D-5L, a new version of the EQ-5D instrument, to support decision-making in the English National Health Service (NHS). The study followed an international research protocol and used a hybrid model to combine time trade-off (TTO) and discrete choice experiment (DCE) data from 996 randomly selected members of the English general public. The resulting value set has a higher minimum value and fewer "worse than dead" states compared to the existing EQ-5D-3L value set. The study found that pain/discomfort and anxiety/depression are the most important health problems, while issues with self-care and usual activities are less significant. The value set will be useful for summarizing EQ-5D-5L data in economic evaluations and resource allocation decisions. The study also addresses methodological issues and provides insights into the preferences of the English population, which can inform decisions in healthcare and health technology assessment.