This paper reviews the current state of virtual reality (VR) applications in motor rehabilitation. It begins with an overview of available equipment, followed by a discussion of the scientific rationale for using VR in rehabilitation. The main part of the paper describes various VR systems developed for patients and the clinical study results. Key areas covered include stroke rehabilitation, acquired brain injury, Parkinson's disease, orthopedic rehabilitation, balance training, wheelchair mobility, and functional activities of daily living training. Four major findings emerge: (1) people with disabilities can learn motor skills in VR environments; (2) movements learned in VR transfer to real-world tasks; (3) VR training generally outperforms real-world training in some studies; and (4) no cases of cybersickness have been reported in impaired populations using VR for motor training. The paper also discusses the advantages of VR in motor learning, such as augmented feedback and facilitation of cortical plasticity, and highlights the potential of VR in rehabilitation, even if it does not offer performance advantages over real-world practice.This paper reviews the current state of virtual reality (VR) applications in motor rehabilitation. It begins with an overview of available equipment, followed by a discussion of the scientific rationale for using VR in rehabilitation. The main part of the paper describes various VR systems developed for patients and the clinical study results. Key areas covered include stroke rehabilitation, acquired brain injury, Parkinson's disease, orthopedic rehabilitation, balance training, wheelchair mobility, and functional activities of daily living training. Four major findings emerge: (1) people with disabilities can learn motor skills in VR environments; (2) movements learned in VR transfer to real-world tasks; (3) VR training generally outperforms real-world training in some studies; and (4) no cases of cybersickness have been reported in impaired populations using VR for motor training. The paper also discusses the advantages of VR in motor learning, such as augmented feedback and facilitation of cortical plasticity, and highlights the potential of VR in rehabilitation, even if it does not offer performance advantages over real-world practice.