The study introduces a novel sex-specific index, the Visceral Adiposity Index (VAI), which is based on waist circumference (WC), body mass index (BMI), triglycerides (TGs), and high-density lipoprotein cholesterol (HDL). The VAI was developed using data from 315 nonobese healthy subjects and validated in 1,498 primary care patients. The VAI was found to be significantly associated with both cardiovascular and cerebrovascular events, independently of classical cardio- and cerebrovascular risk factors. Notably, VAI showed a significant inverse correlation with insulin sensitivity during a euglycemic-hyperinsulinemic clamp. The study concludes that VAI is a valuable indicator of visceral adipose function and insulin sensitivity, strongly associated with cardiometabolic risk. This index could be useful for assessing cardiometabolic risk in clinical practice and population studies.The study introduces a novel sex-specific index, the Visceral Adiposity Index (VAI), which is based on waist circumference (WC), body mass index (BMI), triglycerides (TGs), and high-density lipoprotein cholesterol (HDL). The VAI was developed using data from 315 nonobese healthy subjects and validated in 1,498 primary care patients. The VAI was found to be significantly associated with both cardiovascular and cerebrovascular events, independently of classical cardio- and cerebrovascular risk factors. Notably, VAI showed a significant inverse correlation with insulin sensitivity during a euglycemic-hyperinsulinemic clamp. The study concludes that VAI is a valuable indicator of visceral adipose function and insulin sensitivity, strongly associated with cardiometabolic risk. This index could be useful for assessing cardiometabolic risk in clinical practice and population studies.