This review explores the role of vitamin C as an antioxidant during the healing process after myocardial infarction (MI). The authors discuss the complex mechanisms of vitamin C's adsorption and release kinetics, highlighting its potential as a preventive supplement and therapeutic agent in cardiovascular management. Vitamin C is effective in neutralizing reactive oxygen species (ROS) and protecting biomolecules from oxidative damage. However, its effects are dose-dependent, and excessive intake can have adverse side effects. The review also examines the sources of ROS in the heart, including cytosolic (ctROS) and mitochondrial (mtROS) sources, and their impact on cardiac function. Mitochondrial complexes I and III are identified as key producers of ROS, contributing to cellular damage and death. Vitamin C's ability to scavenge mtROS and maintain intracellular antioxidant levels is emphasized, along with its potential benefits in reducing oxidative stress and improving outcomes in cardiovascular diseases. Despite the controversial nature of vitamin C's effects, preclinical and clinical studies suggest its beneficial role in cardiovascular health, particularly in reducing oxidative stress and improving cardiac function. However, careful dosage management is crucial to avoid potential side effects, such as increased cardiovascular mortality and kidney stone formation. The review concludes by highlighting the need for further research to clarify the time- and dose-dependent effects of vitamin C in cardiovascular disease management.This review explores the role of vitamin C as an antioxidant during the healing process after myocardial infarction (MI). The authors discuss the complex mechanisms of vitamin C's adsorption and release kinetics, highlighting its potential as a preventive supplement and therapeutic agent in cardiovascular management. Vitamin C is effective in neutralizing reactive oxygen species (ROS) and protecting biomolecules from oxidative damage. However, its effects are dose-dependent, and excessive intake can have adverse side effects. The review also examines the sources of ROS in the heart, including cytosolic (ctROS) and mitochondrial (mtROS) sources, and their impact on cardiac function. Mitochondrial complexes I and III are identified as key producers of ROS, contributing to cellular damage and death. Vitamin C's ability to scavenge mtROS and maintain intracellular antioxidant levels is emphasized, along with its potential benefits in reducing oxidative stress and improving outcomes in cardiovascular diseases. Despite the controversial nature of vitamin C's effects, preclinical and clinical studies suggest its beneficial role in cardiovascular health, particularly in reducing oxidative stress and improving cardiac function. However, careful dosage management is crucial to avoid potential side effects, such as increased cardiovascular mortality and kidney stone formation. The review concludes by highlighting the need for further research to clarify the time- and dose-dependent effects of vitamin C in cardiovascular disease management.