The WHO guideline on the care of preterm or low-birth-weight infants provides updated recommendations to improve global care for these vulnerable babies. Premature infants (gestation age <37 weeks) and low-birth-weight infants (<2.5 kg) require complex care to ensure survival, growth, and neurological development. They face increased risks of developmental disorders, infections, nutrition problems, and temperature regulation difficulties, necessitating comprehensive care. The guideline includes 11 strong and 14 conditional recommendations, covering preventive and supportive measures, care for complications, and family involvement. It emphasizes the importance of kangaroo mother care (skin-to-skin contact), exclusive breastfeeding, and appropriate feeding practices. It also recommends the use of continuous positive airway pressure (CPAP) for respiratory support and caffeine for apnea prevention. Family involvement is crucial, with support and education provided to families. The guideline is intended for healthcare professionals, policymakers, and program managers to develop national and regional health strategies. It is based on evidence from numerous studies and follows WHO guidelines for guideline development. The recommendations aim to improve outcomes for preterm and low-birth-weight infants through evidence-based practices.The WHO guideline on the care of preterm or low-birth-weight infants provides updated recommendations to improve global care for these vulnerable babies. Premature infants (gestation age <37 weeks) and low-birth-weight infants (<2.5 kg) require complex care to ensure survival, growth, and neurological development. They face increased risks of developmental disorders, infections, nutrition problems, and temperature regulation difficulties, necessitating comprehensive care. The guideline includes 11 strong and 14 conditional recommendations, covering preventive and supportive measures, care for complications, and family involvement. It emphasizes the importance of kangaroo mother care (skin-to-skin contact), exclusive breastfeeding, and appropriate feeding practices. It also recommends the use of continuous positive airway pressure (CPAP) for respiratory support and caffeine for apnea prevention. Family involvement is crucial, with support and education provided to families. The guideline is intended for healthcare professionals, policymakers, and program managers to develop national and regional health strategies. It is based on evidence from numerous studies and follows WHO guidelines for guideline development. The recommendations aim to improve outcomes for preterm and low-birth-weight infants through evidence-based practices.