The Sixth International Consensus Conference on Intensive Care Medicine, organized by the European Respiratory Society, the American Thoracic Society, the European Society of Intensive Care Medicine, the Society of Critical Care Medicine, and the Société de Réanimation de Langue Française, published a statement on weaning from mechanical ventilation. The conference aimed to address controversies surrounding the process of weaning patients off mechanical ventilation. An 11-member international jury answered five pre-defined questions about weaning. The main recommendations included categorizing patients into three groups based on the difficulty and duration of weaning, considering weaning as early as possible, using spontaneous breathing trials (SBT) to determine extubation success, and using pressure support or assist-control ventilation modes for patients failing initial trials. Noninvasive ventilation techniques were considered for selected patients to shorten intubation duration but should not be routinely used for extubation failure. Weaning from mechanical ventilation is essential for critically ill patients. The process involves liberating the patient from mechanical support and the endotracheal tube, including terminal care aspects. The jury proposed a classification of patients into three groups based on weaning difficulty and duration. Patients who successfully pass the initial SBT and are extubated on the first attempt are in group 1, while those requiring multiple trials or prolonged weaning are in groups 2 and 3. The consensus statement emphasized the importance of early weaning, using SBT, and managing patients with prolonged weaning failure. It also highlighted the need for further research on the effectiveness of noninvasive ventilation and the pathophysiology of weaning failure. The statement provided definitions for weaning success and failure, emphasizing the importance of identifying reversible pathologies and monitoring patients for neuromuscular, metabolic, and endocrine issues. The consensus statement recommended that weaning protocols be implemented to standardize the process and improve patient outcomes.The Sixth International Consensus Conference on Intensive Care Medicine, organized by the European Respiratory Society, the American Thoracic Society, the European Society of Intensive Care Medicine, the Society of Critical Care Medicine, and the Société de Réanimation de Langue Française, published a statement on weaning from mechanical ventilation. The conference aimed to address controversies surrounding the process of weaning patients off mechanical ventilation. An 11-member international jury answered five pre-defined questions about weaning. The main recommendations included categorizing patients into three groups based on the difficulty and duration of weaning, considering weaning as early as possible, using spontaneous breathing trials (SBT) to determine extubation success, and using pressure support or assist-control ventilation modes for patients failing initial trials. Noninvasive ventilation techniques were considered for selected patients to shorten intubation duration but should not be routinely used for extubation failure. Weaning from mechanical ventilation is essential for critically ill patients. The process involves liberating the patient from mechanical support and the endotracheal tube, including terminal care aspects. The jury proposed a classification of patients into three groups based on weaning difficulty and duration. Patients who successfully pass the initial SBT and are extubated on the first attempt are in group 1, while those requiring multiple trials or prolonged weaning are in groups 2 and 3. The consensus statement emphasized the importance of early weaning, using SBT, and managing patients with prolonged weaning failure. It also highlighted the need for further research on the effectiveness of noninvasive ventilation and the pathophysiology of weaning failure. The statement provided definitions for weaning success and failure, emphasizing the importance of identifying reversible pathologies and monitoring patients for neuromuscular, metabolic, and endocrine issues. The consensus statement recommended that weaning protocols be implemented to standardize the process and improve patient outcomes.