This review article discusses the role of Wnt/β-catenin signaling in bone formation, homeostasis, and disease. Wnt signaling is a conserved pathway that regulates various biological processes, including embryonic development and adult tissue homeostasis. The Wnt signaling pathway is divided into two main branches: the canonical Wnt/β-catenin pathway and the non-canonical pathways, such as Wnt/planar cell polarity (PCP) and Wnt/calcium (Ca²⁺) pathways. The canonical pathway is dependent on β-catenin, while the non-canonical pathways are β-catenin-independent. The Wnt signaling pathway plays a crucial role in the pathogenesis of human diseases, including cancers and metabolic disorders. The review summarizes the current understanding of Wnt signaling components and mechanisms in bone formation, homeostasis, and disease. It also discusses the therapeutic strategies for treating bone diseases by targeting Wnt signaling, including extracellular molecules, cytosolic components, and nuclear components of Wnt signaling. The review highlights the importance of Wnt signaling in bone homeostasis and disease, and evaluates the key questions in Wnt signaling that require further exploration. The review also discusses the interaction of Wnt signaling with other signaling pathways, such as Notch, Hedgehog, TGF-β/BMP, PTH, and estrogen signaling. These interactions are essential for the regulation of various biological processes, including embryogenesis, tumorigenesis, and blood-brain barrier development. The review provides a comprehensive overview of the current knowledge of Wnt signaling and its role in bone homeostasis and disease.This review article discusses the role of Wnt/β-catenin signaling in bone formation, homeostasis, and disease. Wnt signaling is a conserved pathway that regulates various biological processes, including embryonic development and adult tissue homeostasis. The Wnt signaling pathway is divided into two main branches: the canonical Wnt/β-catenin pathway and the non-canonical pathways, such as Wnt/planar cell polarity (PCP) and Wnt/calcium (Ca²⁺) pathways. The canonical pathway is dependent on β-catenin, while the non-canonical pathways are β-catenin-independent. The Wnt signaling pathway plays a crucial role in the pathogenesis of human diseases, including cancers and metabolic disorders. The review summarizes the current understanding of Wnt signaling components and mechanisms in bone formation, homeostasis, and disease. It also discusses the therapeutic strategies for treating bone diseases by targeting Wnt signaling, including extracellular molecules, cytosolic components, and nuclear components of Wnt signaling. The review highlights the importance of Wnt signaling in bone homeostasis and disease, and evaluates the key questions in Wnt signaling that require further exploration. The review also discusses the interaction of Wnt signaling with other signaling pathways, such as Notch, Hedgehog, TGF-β/BMP, PTH, and estrogen signaling. These interactions are essential for the regulation of various biological processes, including embryogenesis, tumorigenesis, and blood-brain barrier development. The review provides a comprehensive overview of the current knowledge of Wnt signaling and its role in bone homeostasis and disease.