The article provides a comprehensive overview of Wnt signaling pathways, focusing on their role in developmental processes and homeostasis. Wnt proteins, a large family of conserved growth factors, are involved in a wide range of cellular activities and diseases. The canonical pathway, which involves β-catenin-dependent signaling, is highlighted, detailing the molecular events leading to β-catenin accumulation and nuclear translocation. Key components such as Frizzled (Fz) receptors, low-density lipoprotein receptor-related protein (LRP), and Dishevelled (Dsh) are discussed, along with the regulation of the β-catenin destruction complex by Axin. The article also explores β-catenin-independent signaling, particularly in the context of planar cell polarity (PCP) and axon guidance, and the evolutionary history of the Wnt family. Finally, it emphasizes the ongoing research interest in Wnt signaling, its implications in human diseases, and potential therapeutic applications.The article provides a comprehensive overview of Wnt signaling pathways, focusing on their role in developmental processes and homeostasis. Wnt proteins, a large family of conserved growth factors, are involved in a wide range of cellular activities and diseases. The canonical pathway, which involves β-catenin-dependent signaling, is highlighted, detailing the molecular events leading to β-catenin accumulation and nuclear translocation. Key components such as Frizzled (Fz) receptors, low-density lipoprotein receptor-related protein (LRP), and Dishevelled (Dsh) are discussed, along with the regulation of the β-catenin destruction complex by Axin. The article also explores β-catenin-independent signaling, particularly in the context of planar cell polarity (PCP) and axon guidance, and the evolutionary history of the Wnt family. Finally, it emphasizes the ongoing research interest in Wnt signaling, its implications in human diseases, and potential therapeutic applications.