Wnt proteins are a major family of signaling molecules crucial for various developmental processes, including embryonic induction, cell polarity, and fate specification. Recent advancements have filled several gaps in our understanding of Wnt signaling, including the identification of cell-surface receptors and the mechanism of signal transduction to the nucleus. Wnt signaling pathways have been studied in various organisms, such as mice, *Caenorhabditis elegans*, and *Drosophila*, and have revealed conserved pathways across different species. Key components of Wnt signaling include Fz receptors, Dsh, Axin, β-catenin, and GSK-3. Fz receptors bind Wnt proteins and transduce signals, while Dsh acts as a negative regulator by inhibiting Zw3/GSK-3. Axin is a negative regulator that inhibits β-catenin stabilization, and β-catenin, when stabilized, activates target genes. GSK-3 phosphorylates β-catenin, promoting its degradation. The role of Wnt proteins as morphogens and their interactions with other signaling pathways, such as Hedgehog, are also discussed. The involvement of Wnt signaling in cancer, particularly colorectal cancer, is highlighted, with mutations in Wnt genes contributing to disease development.Wnt proteins are a major family of signaling molecules crucial for various developmental processes, including embryonic induction, cell polarity, and fate specification. Recent advancements have filled several gaps in our understanding of Wnt signaling, including the identification of cell-surface receptors and the mechanism of signal transduction to the nucleus. Wnt signaling pathways have been studied in various organisms, such as mice, *Caenorhabditis elegans*, and *Drosophila*, and have revealed conserved pathways across different species. Key components of Wnt signaling include Fz receptors, Dsh, Axin, β-catenin, and GSK-3. Fz receptors bind Wnt proteins and transduce signals, while Dsh acts as a negative regulator by inhibiting Zw3/GSK-3. Axin is a negative regulator that inhibits β-catenin stabilization, and β-catenin, when stabilized, activates target genes. GSK-3 phosphorylates β-catenin, promoting its degradation. The role of Wnt proteins as morphogens and their interactions with other signaling pathways, such as Hedgehog, are also discussed. The involvement of Wnt signaling in cancer, particularly colorectal cancer, is highlighted, with mutations in Wnt genes contributing to disease development.