Wnt signaling is a key regulator of development and stemness, and has been closely associated with cancer. This review summarizes recent insights into the role of Wnt signaling in cancer, including its functions in solid and liquid tumors, cancer stem cells, metastasis, and immune control. The Wnt pathway is divided into canonical (β-catenin-dependent) and non-canonical signaling pathways. Canonical Wnt signaling is involved in the regulation of β-catenin, which is crucial for colorectal cancer development. Non-canonical Wnt signaling, such as Wnt/PCP and Wnt/Ca²⁺ pathways, plays roles in cell polarity and calcium signaling, and is also involved in cancer progression. Recent studies have identified novel components of the Wnt pathway, including R-spondins, which regulate Wnt signaling through interactions with leucine-rich repeat containing G-protein-coupled receptors (Lgr4-6). Additionally, the role of Wnt signaling in cancer stem cells, metastasis, and immune evasion is discussed. The review also highlights current strategies for targeting Wnt signaling in cancer, including small molecule inhibitors and antibodies, and the challenges associated with these approaches. The importance of Wnt signaling in cancer is further supported by its involvement in various cancer types, including colorectal cancer, pancreatic ductal adenocarcinoma, endometrial cancer, and melanoma. The review concludes that a better understanding of Wnt signaling in cancer is essential for developing effective therapeutic strategies.Wnt signaling is a key regulator of development and stemness, and has been closely associated with cancer. This review summarizes recent insights into the role of Wnt signaling in cancer, including its functions in solid and liquid tumors, cancer stem cells, metastasis, and immune control. The Wnt pathway is divided into canonical (β-catenin-dependent) and non-canonical signaling pathways. Canonical Wnt signaling is involved in the regulation of β-catenin, which is crucial for colorectal cancer development. Non-canonical Wnt signaling, such as Wnt/PCP and Wnt/Ca²⁺ pathways, plays roles in cell polarity and calcium signaling, and is also involved in cancer progression. Recent studies have identified novel components of the Wnt pathway, including R-spondins, which regulate Wnt signaling through interactions with leucine-rich repeat containing G-protein-coupled receptors (Lgr4-6). Additionally, the role of Wnt signaling in cancer stem cells, metastasis, and immune evasion is discussed. The review also highlights current strategies for targeting Wnt signaling in cancer, including small molecule inhibitors and antibodies, and the challenges associated with these approaches. The importance of Wnt signaling in cancer is further supported by its involvement in various cancer types, including colorectal cancer, pancreatic ductal adenocarcinoma, endometrial cancer, and melanoma. The review concludes that a better understanding of Wnt signaling in cancer is essential for developing effective therapeutic strategies.