Wnt signaling, a key pathway regulating development and stemness, has been extensively linked to cancer. This review highlights recent insights into novel components and functions of Wnt pathways in cancer, particularly in solid and liquid tumors. It discusses how Wnt signaling affects cancer stem cell maintenance, metastasis, and immune control. The review also covers current strategies to target Wnt signaling in cancer, including small molecule inhibitors and antibodies, and addresses the challenges associated with these approaches. Key findings include the role of Wnt signaling in gastrointestinal cancers, leukemia, melanoma, and breast cancer, as well as the emerging roles of Wnt signaling in cancer stem cells and anti-tumor immunity. The review emphasizes the complexity and multifaceted nature of Wnt signaling in cancer, highlighting the need for personalized therapeutic approaches.Wnt signaling, a key pathway regulating development and stemness, has been extensively linked to cancer. This review highlights recent insights into novel components and functions of Wnt pathways in cancer, particularly in solid and liquid tumors. It discusses how Wnt signaling affects cancer stem cell maintenance, metastasis, and immune control. The review also covers current strategies to target Wnt signaling in cancer, including small molecule inhibitors and antibodies, and addresses the challenges associated with these approaches. Key findings include the role of Wnt signaling in gastrointestinal cancers, leukemia, melanoma, and breast cancer, as well as the emerging roles of Wnt signaling in cancer stem cells and anti-tumor immunity. The review emphasizes the complexity and multifaceted nature of Wnt signaling in cancer, highlighting the need for personalized therapeutic approaches.