Wnt signaling plays a critical role in cancer development and progression. Aberrant regulation of the Wnt pathway is a common feature in cancer biology, with genetic mutations in Wnt pathway components and epigenetic modifications contributing to tumorigenesis. Key components of the Wnt pathway include the tumor suppressor APC, which is frequently mutated in human cancers, and the oncogene β-catenin, which is activated by mutations. The Wnt pathway interacts with other signaling pathways, such as Notch and EGFR, to promote cancer growth and survival. Epigenetic mechanisms, including DNA methylation and chromatin modifications, also regulate Wnt signaling and its role in cancer. Experimental evidence supports the therapeutic potential of targeting Wnt signaling in cancer, with studies showing that inhibition of Wnt signaling can reduce tumor growth and survival. The Wnt pathway is involved in the regulation of cancer stem cells and is implicated in various cancers, including colorectal, hepatocellular, and breast cancers. The interplay between Wnt signaling and other pathways highlights the complexity of cancer biology and the importance of targeting Wnt signaling for cancer therapy.Wnt signaling plays a critical role in cancer development and progression. Aberrant regulation of the Wnt pathway is a common feature in cancer biology, with genetic mutations in Wnt pathway components and epigenetic modifications contributing to tumorigenesis. Key components of the Wnt pathway include the tumor suppressor APC, which is frequently mutated in human cancers, and the oncogene β-catenin, which is activated by mutations. The Wnt pathway interacts with other signaling pathways, such as Notch and EGFR, to promote cancer growth and survival. Epigenetic mechanisms, including DNA methylation and chromatin modifications, also regulate Wnt signaling and its role in cancer. Experimental evidence supports the therapeutic potential of targeting Wnt signaling in cancer, with studies showing that inhibition of Wnt signaling can reduce tumor growth and survival. The Wnt pathway is involved in the regulation of cancer stem cells and is implicated in various cancers, including colorectal, hepatocellular, and breast cancers. The interplay between Wnt signaling and other pathways highlights the complexity of cancer biology and the importance of targeting Wnt signaling for cancer therapy.