Worldwide variations in colorectal cancer incidence and mortality rates are significant, with higher rates observed in North America, Oceania, and Europe, including Eastern European countries, while lower rates are found in Asia, Africa, and South America. These differences are largely due to lifestyle changes associated with Westernization, such as obesity and physical inactivity. Colorectal cancer mortality rates have decreased in many developed countries, but continue to rise in some low-resource countries. Screening programs are available globally, and targeted initiatives could help reduce the burden of colorectal cancer. The study used the most recent data from the International Agency for Research on Cancer (IARC) to analyze trends in incidence and mortality rates. Colorectal cancer screening options vary, with fecal occult blood tests being more feasible in many regions. Despite these variations, colorectal cancer screening has been shown to reduce mortality and may prevent the onset of disease by removing precancerous polyps. The study highlights the need for international consideration of targeted screening programs to address the global burden of colorectal cancer.Worldwide variations in colorectal cancer incidence and mortality rates are significant, with higher rates observed in North America, Oceania, and Europe, including Eastern European countries, while lower rates are found in Asia, Africa, and South America. These differences are largely due to lifestyle changes associated with Westernization, such as obesity and physical inactivity. Colorectal cancer mortality rates have decreased in many developed countries, but continue to rise in some low-resource countries. Screening programs are available globally, and targeted initiatives could help reduce the burden of colorectal cancer. The study used the most recent data from the International Agency for Research on Cancer (IARC) to analyze trends in incidence and mortality rates. Colorectal cancer screening options vary, with fecal occult blood tests being more feasible in many regions. Despite these variations, colorectal cancer screening has been shown to reduce mortality and may prevent the onset of disease by removing precancerous polyps. The study highlights the need for international consideration of targeted screening programs to address the global burden of colorectal cancer.