This article provides a comprehensive overview of the global burden and patterns of colorectal cancer, using the most recent data from the International Agency for Research on Cancer (IARC). It highlights significant international variations in incidence and mortality rates, with the highest incidence rates observed in North America, Oceania, and Europe, particularly in Eastern European countries, likely due to increased risk factors such as obesity and physical inactivity. In contrast, the lowest incidence rates are found in Asia, Africa, and South America. Mortality rates have declined in many longstanding and newly economically developed countries but continue to rise in some low-resource countries like South America and Eastern Europe. The article also discusses various screening options, including fecal occult blood tests (FOBTs) and colonoscopies, and notes that the implementation of targeted screening programs could help reduce the global burden of colorectal cancer.This article provides a comprehensive overview of the global burden and patterns of colorectal cancer, using the most recent data from the International Agency for Research on Cancer (IARC). It highlights significant international variations in incidence and mortality rates, with the highest incidence rates observed in North America, Oceania, and Europe, particularly in Eastern European countries, likely due to increased risk factors such as obesity and physical inactivity. In contrast, the lowest incidence rates are found in Asia, Africa, and South America. Mortality rates have declined in many longstanding and newly economically developed countries but continue to rise in some low-resource countries like South America and Eastern Europe. The article also discusses various screening options, including fecal occult blood tests (FOBTs) and colonoscopies, and notes that the implementation of targeted screening programs could help reduce the global burden of colorectal cancer.