This literature review summarizes the complex processes involved in wound healing, focusing on the cellular and molecular mechanisms that occur during skin repair. Wound healing is a dynamic process involving multiple stages: inflammation, proliferation, and remodeling. The inflammatory phase is characterized by the influx of leukocytes, which help clear debris and initiate the healing process. This is followed by the proliferative phase, where cell proliferation and the synthesis of extracellular matrix components occur, leading to tissue repair and regeneration. The remodeling phase involves the reorganization and strengthening of the extracellular matrix, resulting in the formation of scar tissue. Key cellular players in wound healing include macrophages, fibroblasts, and endothelial cells, which contribute to tissue repair through the release of growth factors and cytokines. The Hedgehog signaling pathway is highlighted as a critical regulator of tissue repair, influencing cell proliferation, differentiation, and matrix remodeling. Additionally, epithelial-mesenchymal transitions (EMT) play a role in wound healing, allowing epithelial cells to adopt mesenchymal characteristics to facilitate tissue repair. The review also discusses the importance of signaling molecules such as Wnt, Notch, and Hedgehog in regulating the various stages of wound healing. These pathways are essential for the proper development and maintenance of tissues, and their dysregulation can lead to impaired healing. Factors such as diabetes, immunosuppression, and smoking can hinder the healing process, while conditions like hypertrophic scars and keloids may result from abnormal tissue remodeling. Overall, wound healing is a highly regulated process involving a complex interplay of cellular and molecular events. Understanding these mechanisms is crucial for developing effective therapeutic strategies to promote tissue repair and regeneration.This literature review summarizes the complex processes involved in wound healing, focusing on the cellular and molecular mechanisms that occur during skin repair. Wound healing is a dynamic process involving multiple stages: inflammation, proliferation, and remodeling. The inflammatory phase is characterized by the influx of leukocytes, which help clear debris and initiate the healing process. This is followed by the proliferative phase, where cell proliferation and the synthesis of extracellular matrix components occur, leading to tissue repair and regeneration. The remodeling phase involves the reorganization and strengthening of the extracellular matrix, resulting in the formation of scar tissue. Key cellular players in wound healing include macrophages, fibroblasts, and endothelial cells, which contribute to tissue repair through the release of growth factors and cytokines. The Hedgehog signaling pathway is highlighted as a critical regulator of tissue repair, influencing cell proliferation, differentiation, and matrix remodeling. Additionally, epithelial-mesenchymal transitions (EMT) play a role in wound healing, allowing epithelial cells to adopt mesenchymal characteristics to facilitate tissue repair. The review also discusses the importance of signaling molecules such as Wnt, Notch, and Hedgehog in regulating the various stages of wound healing. These pathways are essential for the proper development and maintenance of tissues, and their dysregulation can lead to impaired healing. Factors such as diabetes, immunosuppression, and smoking can hinder the healing process, while conditions like hypertrophic scars and keloids may result from abnormal tissue remodeling. Overall, wound healing is a highly regulated process involving a complex interplay of cellular and molecular events. Understanding these mechanisms is crucial for developing effective therapeutic strategies to promote tissue repair and regeneration.