The article "Wound Repair and Regeneration: Mechanisms, Signaling, and Translation" by Sabine A. Eming, Paul Martin, and Marjana Tomic-Canic provides an in-depth review of the cellular and molecular mechanisms underlying tissue repair and regeneration, focusing on wound healing. The authors highlight the current limitations in understanding and treating wound healing disorders, such as chronic wounds and pathological scarring, which affect millions of people worldwide. They discuss the complex interplay between inflammation, angiogenesis, matrix deposition, and cell recruitment in the wound healing process, emphasizing the role of various signaling pathways and the importance of a comprehensive understanding of these mechanisms for developing effective therapeutic strategies. The article also reviews the challenges in translating basic research findings into clinical applications, including the lack of preclinical models that accurately recapitulate human conditions, the complexity of multifactorial etiologies, and the need for large-scale clinical trials. It explores the potential of using animal models, particularly mice, Drosophila, and zebrafish, to study wound healing and regeneration, highlighting their advantages and limitations. Additionally, the authors discuss the role of extracellular matrix (ECM) and growth factors in wound healing, emphasizing the importance of understanding their interactions and the potential for ECM-based therapeutic systems. They also address the limitations of current treatments, such as wound dressings and growth factor delivery, and the need for combination therapies to improve outcomes. Finally, the article emphasizes the importance of translating basic research findings into clinical approaches, considering the complex nature of wound healing pathologies and the need for a comprehensive understanding of the interactions between different components of the healing process. The authors conclude by highlighting the potential of regenerating organisms, such as zebrafish and salamanders, to provide insights into enhancing normal wound-healing mechanisms and regenerative capacities.The article "Wound Repair and Regeneration: Mechanisms, Signaling, and Translation" by Sabine A. Eming, Paul Martin, and Marjana Tomic-Canic provides an in-depth review of the cellular and molecular mechanisms underlying tissue repair and regeneration, focusing on wound healing. The authors highlight the current limitations in understanding and treating wound healing disorders, such as chronic wounds and pathological scarring, which affect millions of people worldwide. They discuss the complex interplay between inflammation, angiogenesis, matrix deposition, and cell recruitment in the wound healing process, emphasizing the role of various signaling pathways and the importance of a comprehensive understanding of these mechanisms for developing effective therapeutic strategies. The article also reviews the challenges in translating basic research findings into clinical applications, including the lack of preclinical models that accurately recapitulate human conditions, the complexity of multifactorial etiologies, and the need for large-scale clinical trials. It explores the potential of using animal models, particularly mice, Drosophila, and zebrafish, to study wound healing and regeneration, highlighting their advantages and limitations. Additionally, the authors discuss the role of extracellular matrix (ECM) and growth factors in wound healing, emphasizing the importance of understanding their interactions and the potential for ECM-based therapeutic systems. They also address the limitations of current treatments, such as wound dressings and growth factor delivery, and the need for combination therapies to improve outcomes. Finally, the article emphasizes the importance of translating basic research findings into clinical approaches, considering the complex nature of wound healing pathologies and the need for a comprehensive understanding of the interactions between different components of the healing process. The authors conclude by highlighting the potential of regenerating organisms, such as zebrafish and salamanders, to provide insights into enhancing normal wound-healing mechanisms and regenerative capacities.