The article discusses the mechanisms and challenges of wound repair and regeneration, emphasizing the need for better understanding of the biological processes involved in tissue healing and the development of effective clinical strategies. It highlights the complexity of wound healing, which involves multiple cellular and molecular processes, including inflammation, angiogenesis, and matrix deposition. The failure of these processes can lead to chronic wounds and pathological scarring, which are major clinical challenges. The article reviews the current state of research and treatment options, noting that while some therapies exist, they are often limited in effectiveness. It also discusses the role of various factors, including stem cells, proteases, and inflammatory responses, in wound healing. The article emphasizes the need for further research and the development of new therapeutic approaches that can improve wound healing and reduce scarring. It also highlights the importance of animal models in understanding the mechanisms of wound healing and the potential for translating findings from these models to clinical applications. The article concludes by emphasizing the need for a more comprehensive understanding of the biological processes involved in wound healing to develop effective treatments for patients with chronic wounds and scarring.The article discusses the mechanisms and challenges of wound repair and regeneration, emphasizing the need for better understanding of the biological processes involved in tissue healing and the development of effective clinical strategies. It highlights the complexity of wound healing, which involves multiple cellular and molecular processes, including inflammation, angiogenesis, and matrix deposition. The failure of these processes can lead to chronic wounds and pathological scarring, which are major clinical challenges. The article reviews the current state of research and treatment options, noting that while some therapies exist, they are often limited in effectiveness. It also discusses the role of various factors, including stem cells, proteases, and inflammatory responses, in wound healing. The article emphasizes the need for further research and the development of new therapeutic approaches that can improve wound healing and reduce scarring. It also highlights the importance of animal models in understanding the mechanisms of wound healing and the potential for translating findings from these models to clinical applications. The article concludes by emphasizing the need for a more comprehensive understanding of the biological processes involved in wound healing to develop effective treatments for patients with chronic wounds and scarring.