The ZDOCK server is a user-friendly web interface for predicting protein–protein complexes and symmetric multimers using the rigid-body docking programs ZDOCK and M-ZDOCK. The server provides an intuitive interface for users to guide scoring and selection of output models, along with dynamic visualization of input structures and docking results. It has been improved over the years to enhance docking performance and user experience, including the upgrade from ZDOCK 2.3 to ZDOCK 3.0.2 and the addition of M-ZDOCK for symmetric multimer docking. The server is freely available to academic and non-profit users, with no registration required. Since its implementation, the ZDOCK Server has completed over 6200 jobs from more than 1000 unique users, demonstrating its efficiency and effectiveness in producing high-quality docking models.The ZDOCK server is a user-friendly web interface for predicting protein–protein complexes and symmetric multimers using the rigid-body docking programs ZDOCK and M-ZDOCK. The server provides an intuitive interface for users to guide scoring and selection of output models, along with dynamic visualization of input structures and docking results. It has been improved over the years to enhance docking performance and user experience, including the upgrade from ZDOCK 2.3 to ZDOCK 3.0.2 and the addition of M-ZDOCK for symmetric multimer docking. The server is freely available to academic and non-profit users, with no registration required. Since its implementation, the ZDOCK Server has completed over 6200 jobs from more than 1000 unique users, demonstrating its efficiency and effectiveness in producing high-quality docking models.