This study investigates the role of circular RNA (circRNA) circRPPH1 in triple-negative breast cancer (TNBC) and its underlying mechanisms. CircRPPH1 is upregulated in TNBC tissues and cells, correlating with poor prognosis and advanced TNM staging. In vitro and in vivo experiments demonstrate that circRPPH1 promotes TNBC cell growth, migration, and invasion. Mechanistically, the transcription factor ZNF460 is identified as a regulator of circRPPH1 expression. CircRPPH1 functions as a molecular sponge for miR-326, binding to it and inhibiting its degradation. This interaction leads to increased ITGA5 expression, which activates the FAK/PI3K/AKT pathway. The study concludes that circRPPH1 can serve as a therapeutic and diagnostic target for TNBC.This study investigates the role of circular RNA (circRNA) circRPPH1 in triple-negative breast cancer (TNBC) and its underlying mechanisms. CircRPPH1 is upregulated in TNBC tissues and cells, correlating with poor prognosis and advanced TNM staging. In vitro and in vivo experiments demonstrate that circRPPH1 promotes TNBC cell growth, migration, and invasion. Mechanistically, the transcription factor ZNF460 is identified as a regulator of circRPPH1 expression. CircRPPH1 functions as a molecular sponge for miR-326, binding to it and inhibiting its degradation. This interaction leads to increased ITGA5 expression, which activates the FAK/PI3K/AKT pathway. The study concludes that circRPPH1 can serve as a therapeutic and diagnostic target for TNBC.