Circular RNA circRPPH1 promotes triple-negative breast cancer (TNBC) progression by activating the FAK/PI3K/AKT pathway through miR-326 and ITGA5. The study reveals that circRPPH1 is upregulated in TNBC tissues and is associated with poor prognosis. It functions as a molecular sponge for miR-326, thereby inhibiting the degradation of ITGA5 and activating the FAK/PI3K/AKT pathway. The transcription factor ZNF460 promotes circRPPH1 expression. CircRPPH1 enhances TNBC cell proliferation, migration, and invasion. It also promotes EMT, regulates the cell cycle, and inhibits apoptosis in TNBC cells. The circRPPH1/miR-326/ITGA5 axis contributes to TNBC progression by activating the FAK/PI3K/AKT pathway. These findings suggest that circRPPH1 could serve as a therapeutic or diagnostic target for TNBC.Circular RNA circRPPH1 promotes triple-negative breast cancer (TNBC) progression by activating the FAK/PI3K/AKT pathway through miR-326 and ITGA5. The study reveals that circRPPH1 is upregulated in TNBC tissues and is associated with poor prognosis. It functions as a molecular sponge for miR-326, thereby inhibiting the degradation of ITGA5 and activating the FAK/PI3K/AKT pathway. The transcription factor ZNF460 promotes circRPPH1 expression. CircRPPH1 enhances TNBC cell proliferation, migration, and invasion. It also promotes EMT, regulates the cell cycle, and inhibits apoptosis in TNBC cells. The circRPPH1/miR-326/ITGA5 axis contributes to TNBC progression by activating the FAK/PI3K/AKT pathway. These findings suggest that circRPPH1 could serve as a therapeutic or diagnostic target for TNBC.