The passage discusses the challenges in diagnosing *Burkholderia pseudomallei* infections, particularly in patients with pneumonia after travel to the Baja Peninsula in Mexico, especially following extreme weather events. The phenotypic tests used to differentiate *B. pseudomallei* from other Burkholderia species are often insufficient, and the need for reference spectra for the organism and its relatives is highlighted. Due to the risk of transmission to laboratory workers and potential bioterrorism, clinical laboratories should perform limited testing before referring suspected isolates to public health laboratories for definitive identification. The acknowledgment section credits the Multi-Locus Sequence Typing website at Imperial College London for its development and support. The references include a study on the misidentification of *B. pseudomallei* using the Vitek 2 system.The passage discusses the challenges in diagnosing *Burkholderia pseudomallei* infections, particularly in patients with pneumonia after travel to the Baja Peninsula in Mexico, especially following extreme weather events. The phenotypic tests used to differentiate *B. pseudomallei* from other Burkholderia species are often insufficient, and the need for reference spectra for the organism and its relatives is highlighted. Due to the risk of transmission to laboratory workers and potential bioterrorism, clinical laboratories should perform limited testing before referring suspected isolates to public health laboratories for definitive identification. The acknowledgment section credits the Multi-Locus Sequence Typing website at Imperial College London for its development and support. The references include a study on the misidentification of *B. pseudomallei* using the Vitek 2 system.