A therapeutic circRNA, circCDK13, was loaded into small extracellular vesicles (sEVs) to treat diabetic wounds in preclinical models. circCDK13 promotes the proliferation and migration of human dermal fibroblasts (HDFs) and human epidermal keratinocytes (HEKs) by interacting with IGF2BP3 in an m6A-dependent manner, enhancing CD44 and c-MYC expression. Engineered sEVs overexpressing circCDK13 accelerated wound healing and skin appendage regeneration in diabetic mice and rats. The study demonstrates that circCDK13-loaded sEVs may offer a promising therapeutic strategy for diabetic wound healing. circCDK13 was found to be downregulated in diabetic wounds and plays a critical role in regulating the proliferation and migration of HDFs and HEKs. The interaction between circCDK13 and IGF2BP3 enhances the stability of each other, promoting the expression of CD44 and c-MYC, which are essential for wound healing. circCDK13-loaded sEVs showed enhanced efficacy in promoting cell proliferation and migration compared to natural MSC-derived sEVs. The study highlights the potential of circCDK13-loaded sEVs as a novel therapeutic approach for diabetic wound healing.A therapeutic circRNA, circCDK13, was loaded into small extracellular vesicles (sEVs) to treat diabetic wounds in preclinical models. circCDK13 promotes the proliferation and migration of human dermal fibroblasts (HDFs) and human epidermal keratinocytes (HEKs) by interacting with IGF2BP3 in an m6A-dependent manner, enhancing CD44 and c-MYC expression. Engineered sEVs overexpressing circCDK13 accelerated wound healing and skin appendage regeneration in diabetic mice and rats. The study demonstrates that circCDK13-loaded sEVs may offer a promising therapeutic strategy for diabetic wound healing. circCDK13 was found to be downregulated in diabetic wounds and plays a critical role in regulating the proliferation and migration of HDFs and HEKs. The interaction between circCDK13 and IGF2BP3 enhances the stability of each other, promoting the expression of CD44 and c-MYC, which are essential for wound healing. circCDK13-loaded sEVs showed enhanced efficacy in promoting cell proliferation and migration compared to natural MSC-derived sEVs. The study highlights the potential of circCDK13-loaded sEVs as a novel therapeutic approach for diabetic wound healing.