The circlize package is an R package that provides an efficient and flexible implementation of circular layout generation for visualizing genomic data. It allows users to create circular plots, which are particularly useful for displaying large amounts of genomic information. The package is based on low-level graphics functions, enabling users to customize and implement their own high-level graphics for specific purposes. It integrates seamlessly with R's powerful data analysis and visualization environment, making it easier to design figures for better understanding of genomic patterns. Circlize offers a general and flexible solution for circular layouts. It provides basic low-level graphics functions that allow users to create more complex graphics. The package supports a wide range of data types and can be used for various applications beyond genomics. It includes functions for genomic data visualization, such as circos.genomicPoints, circos.initializeWithIdeogram, and circos.genomicDensity, which facilitate the display of genomic features. The package allows users to create circular layouts by following a simple process: initializing the layout, creating plotting regions, adding basic graphics, and repeating these steps for multiple tracks. It also supports advanced features such as nested circular layouts and direct comparisons between experimental conditions. The package is available on CRAN and is designed to be user-friendly and extendable, making it a valuable tool for genomic data visualization.The circlize package is an R package that provides an efficient and flexible implementation of circular layout generation for visualizing genomic data. It allows users to create circular plots, which are particularly useful for displaying large amounts of genomic information. The package is based on low-level graphics functions, enabling users to customize and implement their own high-level graphics for specific purposes. It integrates seamlessly with R's powerful data analysis and visualization environment, making it easier to design figures for better understanding of genomic patterns. Circlize offers a general and flexible solution for circular layouts. It provides basic low-level graphics functions that allow users to create more complex graphics. The package supports a wide range of data types and can be used for various applications beyond genomics. It includes functions for genomic data visualization, such as circos.genomicPoints, circos.initializeWithIdeogram, and circos.genomicDensity, which facilitate the display of genomic features. The package allows users to create circular layouts by following a simple process: initializing the layout, creating plotting regions, adding basic graphics, and repeating these steps for multiple tracks. It also supports advanced features such as nested circular layouts and direct comparisons between experimental conditions. The package is available on CRAN and is designed to be user-friendly and extendable, making it a valuable tool for genomic data visualization.