iMOSFLM is a new graphical user interface (GUI) for the diffraction data-integration program MOSFLM, designed to simplify the data processing workflow by dividing it into a series of steps, each with its own display pane for parameter control and graphical feedback. The GUI supports both experienced and inexperienced users, offering detailed control over integration parameters while providing automatic settings for suitable values. Key features include an intuitive image display, detailed task interfaces (indexing, strategy calculation, cell refinement, integration, and history), and tools for assessing processing success or failure. The article discusses the overall structure of the iMOSFLM GUI, the individual task panes, and specific parameters and troubleshooting tips for each step. The software is distributed with the CCP4 package and is actively being developed to enhance performance and functionality.iMOSFLM is a new graphical user interface (GUI) for the diffraction data-integration program MOSFLM, designed to simplify the data processing workflow by dividing it into a series of steps, each with its own display pane for parameter control and graphical feedback. The GUI supports both experienced and inexperienced users, offering detailed control over integration parameters while providing automatic settings for suitable values. Key features include an intuitive image display, detailed task interfaces (indexing, strategy calculation, cell refinement, integration, and history), and tools for assessing processing success or failure. The article discusses the overall structure of the iMOSFLM GUI, the individual task panes, and specific parameters and troubleshooting tips for each step. The software is distributed with the CCP4 package and is actively being developed to enhance performance and functionality.