The study identifies the role of the YTHDF2 protein in regulating mRNA stability through recognition of the m6A modification. YTHDF2 selectively binds to m6A-containing mRNA and influences its degradation. The research shows that YTHDF2 localizes m6A-containing mRNA to decay sites, such as processing bodies, and that its C-terminal domain binds to m6A-containing mRNA while the N-terminal domain facilitates localization to decay sites. The study also reveals that m6A modification is dynamically regulated by m6A methyltransferases and demethylases, and that YTHDF2 acts as a reader protein to modulate mRNA stability and translation. The findings highlight the importance of m6A modification in mRNA metabolism and its potential role in cellular processes such as development and disease. The study provides a comprehensive understanding of the m6A modification's role in mRNA regulation and its implications for cellular function.The study identifies the role of the YTHDF2 protein in regulating mRNA stability through recognition of the m6A modification. YTHDF2 selectively binds to m6A-containing mRNA and influences its degradation. The research shows that YTHDF2 localizes m6A-containing mRNA to decay sites, such as processing bodies, and that its C-terminal domain binds to m6A-containing mRNA while the N-terminal domain facilitates localization to decay sites. The study also reveals that m6A modification is dynamically regulated by m6A methyltransferases and demethylases, and that YTHDF2 acts as a reader protein to modulate mRNA stability and translation. The findings highlight the importance of m6A modification in mRNA metabolism and its potential role in cellular processes such as development and disease. The study provides a comprehensive understanding of the m6A modification's role in mRNA regulation and its implications for cellular function.