The article presents the identification and characterization of mPPARγ2, a novel member of the peroxisome proliferator-activated receptor (PPAR) family, which functions as a tissue-specific regulator of an adipocyte enhancer. Researchers, including Peter Tontonoz, Erding Hu, Reed A. Graves, Adriane I. Budavari, and Bruce M. Spiegelman, discovered that mPPARγ2 forms a heterodimer with retinoid X receptors (RXRs) to bind to ARF6-binding sites in the adipocyte P2 (ap2) gene enhancer. This complex is crucial for adipocyte-specific gene expression. mPPARγ2 is highly expressed in adipose tissue and is induced early during adipocyte differentiation. It activates the ap2 enhancer in non-adipose cells and is potentiated by peroxisome proliferators, fatty acids, and 9-cis retinoic acid. The study demonstrates that mPPARγ2 is the first adipocyte-specific transcription factor identified, providing insights into how lipids regulate adipocyte gene expression and differentiation. The findings suggest that mPPARγ2 plays a key role in adipogenesis by interacting with ARF6, a cell type-restricted nuclear factor. The research highlights the molecular mechanisms underlying adipocyte-specific gene regulation and the role of PPARs in lipid metabolism and adipose tissue development. The study also identifies mPPARγ2 as a potential target for therapies related to adipose function and metabolic diseases.The article presents the identification and characterization of mPPARγ2, a novel member of the peroxisome proliferator-activated receptor (PPAR) family, which functions as a tissue-specific regulator of an adipocyte enhancer. Researchers, including Peter Tontonoz, Erding Hu, Reed A. Graves, Adriane I. Budavari, and Bruce M. Spiegelman, discovered that mPPARγ2 forms a heterodimer with retinoid X receptors (RXRs) to bind to ARF6-binding sites in the adipocyte P2 (ap2) gene enhancer. This complex is crucial for adipocyte-specific gene expression. mPPARγ2 is highly expressed in adipose tissue and is induced early during adipocyte differentiation. It activates the ap2 enhancer in non-adipose cells and is potentiated by peroxisome proliferators, fatty acids, and 9-cis retinoic acid. The study demonstrates that mPPARγ2 is the first adipocyte-specific transcription factor identified, providing insights into how lipids regulate adipocyte gene expression and differentiation. The findings suggest that mPPARγ2 plays a key role in adipogenesis by interacting with ARF6, a cell type-restricted nuclear factor. The research highlights the molecular mechanisms underlying adipocyte-specific gene regulation and the role of PPARs in lipid metabolism and adipose tissue development. The study also identifies mPPARγ2 as a potential target for therapies related to adipose function and metabolic diseases.