The study investigates the role of miR-15a and miR-16-1 in regulating BCL2 expression in chronic lymphocytic leukemia (CLL). The results show that miR-15a and miR-16-1 are inversely correlated with BCL2 expression in CLL cells, and both microRNAs negatively regulate BCL2 at the posttranscriptional level. Transfection experiments in the MEG-01 cell line, a leukemia-derived cell line, demonstrate that both miRNAs reduce BCL2 protein levels and induce apoptosis by activating the intrinsic apoptosis pathway. The study also highlights the therapeutic potential of targeting miR-15a and miR-16-1 in BCL2-overexpressing tumors.The study investigates the role of miR-15a and miR-16-1 in regulating BCL2 expression in chronic lymphocytic leukemia (CLL). The results show that miR-15a and miR-16-1 are inversely correlated with BCL2 expression in CLL cells, and both microRNAs negatively regulate BCL2 at the posttranscriptional level. Transfection experiments in the MEG-01 cell line, a leukemia-derived cell line, demonstrate that both miRNAs reduce BCL2 protein levels and induce apoptosis by activating the intrinsic apoptosis pathway. The study also highlights the therapeutic potential of targeting miR-15a and miR-16-1 in BCL2-overexpressing tumors.